ENSG00000110931


Homo sapiens

Features
Gene ID: ENSG00000110931
  
Biological name :CAMKK2
  
Synonyms : calcium/calmodulin dependent protein kinase kinase 2 / CAMKK2 / Q96RR4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 121237691
Gene end: 121298308
  
Corresponding Affymetrix probe sets: 207359_at (Human Genome U133 Plus 2.0 Array)   210787_s_at (Human Genome U133 Plus 2.0 Array)   212252_at (Human Genome U133 Plus 2.0 Array)   213812_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388368
Ensembl peptide - ENSP00000388273
Ensembl peptide - ENSP00000441352
Ensembl peptide - ENSP00000445944
Ensembl peptide - ENSP00000445400
Ensembl peptide - ENSP00000444894
Ensembl peptide - ENSP00000312741
Ensembl peptide - ENSP00000321230
Ensembl peptide - ENSP00000336634
Ensembl peptide - ENSP00000376265
Ensembl peptide - ENSP00000376266
Ensembl peptide - ENSP00000384591
Ensembl peptide - ENSP00000384600
NCBI entrez gene - 10645     See in Manteia.
OMIM - 615002
RefSeq - XM_017018709
RefSeq - XM_011537763
RefSeq - XM_011537764
RefSeq - XM_017018694
RefSeq - XM_017018695
RefSeq - XM_017018696
RefSeq - XM_017018697
RefSeq - XM_017018698
RefSeq - XM_017018699
RefSeq - XM_017018700
RefSeq - XM_017018701
RefSeq - XM_017018702
RefSeq - XM_017018703
RefSeq - XM_017018704
RefSeq - XM_017018705
RefSeq - XM_017018706
RefSeq - XM_017018707
RefSeq - XM_017018708
RefSeq - NM_001270485
RefSeq - NM_001270486
RefSeq - NM_006549
RefSeq - NM_153499
RefSeq - NM_153500
RefSeq - NM_172214
RefSeq - NM_172215
RefSeq - NM_172216
RefSeq - NM_172226
RefSeq - XM_005253822
RefSeq - XM_005253823
RefSeq - XM_005253824
RefSeq Peptide - NP_001257415
RefSeq Peptide - NP_006540
RefSeq Peptide - NP_705719
RefSeq Peptide - NP_705720
RefSeq Peptide - NP_757363
RefSeq Peptide - NP_757364
RefSeq Peptide - NP_757365
RefSeq Peptide - NP_757380
RefSeq Peptide - NP_001257414
swissprot - A0A024RBQ0
swissprot - A0A024RBP8
swissprot - F5GZ00
swissprot - F5H360
swissprot - F5H4I7
swissprot - A0A024RBQ3
swissprot - Q96RR4
swissprot - A0A024RBP6
Ensembl - ENSG00000110931
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-62l21.1ENSDARG00000078645Danio rerio
 CAMKK2ENSGALG00000040131Gallus gallus
 Camkk2ENSMUSG00000029471Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAMKK1 / Q8N5S9 / calcium/calmodulin dependent protein kinase kinase 1ENSG0000000466049
STK11 / Q15831 / serine/threonine kinase 11ENSG0000011804622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling TAS
 biological_processGO:0034614 cellular response to reactive oxygen species TAS
 biological_processGO:0045859 regulation of protein kinase activity TAS
 biological_processGO:0045860 positive regulation of protein kinase activity IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0061762 CAMKK-AMPK signaling cascade IMP
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IC
 cellular_componentGO:0005622 intracellular IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005516 calmodulin binding TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr