ENSGALG00000040008


Gallus gallus

Features
Gene ID: ENSGALG00000040008
  
Biological name :STK11
  
Synonyms : Q0GGW5 / Serine/threonine-protein kinase STK11 / STK11
  
Possible biological names infered from orthology : Q15831 / Q9WTK7 / serine/threonine kinase 11
  
Species: Gallus gallus
  
Chr. number: 28
Strand: 1
Band:
Gene start: 3020700
Gene end: 3054781
  
Corresponding Affymetrix probe sets: Gga.12596.1.S1_at (Chicken Array)   GgaAffx.1753.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055443
NCBI entrez gene - 420105     See in Manteia.
RefSeq - NM_001045833
RefSeq - XM_015299932
RefSeq Peptide - NP_001039298
swissprot - Q0GGW5
Ensembl - ENSGALG00000040008
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk11ENSDARG00000046074Danio rerio
 STK11ENSG00000118046Homo sapiens
 Stk11ENSMUSG00000003068Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAMKK2 / calcium/calmodulin dependent protein kinase kinase 2 / Q8C078* / Q96RR4*ENSGALG0000004013128
CAMKK1 / calcium/calmodulin dependent protein kinase kinase 1 / Q8N5S9* / Q8VBY2*ENSGALG0000000161726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001894 tissue homeostasis IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0036399 TCR signalosome assembly IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043276 anoikis IEA
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051055 negative regulation of lipid biosynthetic process IEA
 biological_processGO:0051645 Golgi localization IEA
 biological_processGO:0051896 regulation of protein kinase B signaling IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IEA
 biological_processGO:0071493 cellular response to UV-B IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:0097484 dendrite extension IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0036398 TCR signalosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030275 LRR domain binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Energy dependent regulation of mTOR by LKB1-AMPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000550 STRADA / Q5ZK47 / STE20-related kinase adapter protein alpha / Q7RTN6* / Q3UUJ4* / STE20-related kinase adaptor alpha*  / complex / reaction
 ENSGALG00000017005 CAB39L / calcium binding protein 39 like / Q9DB16* / Q9H9S4*  / reaction / complex
 ENSGALG00000014832 PRKAA1 / protein kinase AMP-activated catalytic subunit alpha 1 / Q13131* / Q5EG47* / protein kinase, AMP-activated, alpha 1 catalytic subunit*  / reaction
 ENSGALG00000007373 PRKAB1 / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-activated, beta 1 non-catalytic subunit*  / reaction
 ENSGALG00000001678 PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2 / O43741* / Q6PAM0* / protein kinase, AMP-activated, beta 2 non-catalytic subunit*  / reaction
 ENSGALG00000027262 CAB39 / calcium binding protein 39 / Q06138* / Q9Y376* / Mus musculus calcium binding protein 39 (Cab39), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000011360 PRKAG3 / 5-AMP-activated protein kinase subunit gamma-3 / Q9UGI9* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-activated, gamma 3 non-catat...  / reaction
 ENSGALG00000010826 PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2 / P54646* / Q8BRK8* / protein kinase, AMP-activated, alpha 2 catalytic subunit*  / reaction
 ENSGALG00000036282 O54950* / P54619* / PRKAG1* / protein kinase AMP-activated non-catalytic subunit gamma 1* / protein kinase, AMP-activated, gamma 1 non-catalytic subunit*  / reaction






 

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