ENSGALG00000010826


Gallus gallus

Features
Gene ID: ENSGALG00000010826
  
Biological name :PRKAA2
  
Synonyms : PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2
  
Possible biological names infered from orthology : P54646 / protein kinase, AMP-activated, alpha 2 catalytic subunit / Q8BRK8
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 25836881
Gene end: 25855498
  
Corresponding Affymetrix probe sets: GgaAffx.6840.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017580
NCBI entrez gene - 429110     See in Manteia.
RefSeq - NM_001039605
RefSeq - XM_015291061
RefSeq Peptide - NP_001034694
swissprot - Q2LAI0
Ensembl - ENSGALG00000010826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkaa2ENSDARG00000060641Danio rerio
 P54646ENSG00000162409Homo sapiens
 Prkaa2ENSMUSG00000028518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKAA1 / protein kinase AMP-activated catalytic subunit alpha 1 / Q13131* / Q5EG47* / protein kinase, AMP-activated, alpha 1 catalytic subunit*ENSGALG0000001483275
NUAK1 / NUAK family kinase 1 / O60285* / Q641K5* / NUAK family SNF1-like kinase 1 *ENSGALG0000001266231
NUAK2 / NUAK family kinase 2 / Q8BZN4* / Q9H093* / NUAK family SNF1-like kinase 2 *ENSGALG0000003661628
TRIB1 / tribbles pseudokinase 1 / Q8K4K4* / Q96RU8* / Tribbles homolog 1 *ENSGALG0000003645614
TRIB2 / tribbles homolog 2 / Q8K4K3* / Q92519* / tribbles pseudokinase 2*ENSGALG0000001645714
STK40 / serine/threonine-protein kinase 40 / Q7TNL3* / Q8N2I9* / serine/threonine kinase 40*ENSGALG0000003292512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR032270  AMPK, C-terminal adenylate sensor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0008610 lipid biosynthetic process IEA
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0016241 regulation of macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031649 heat generation IDA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IDA
 biological_processGO:0035404 histone-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:1904101 response to acadesine IDA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004679 AMP-activated protein kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035174 histone serine kinase activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
Import of palmitoyl-CoA into the mitochondrial matrix
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001678 PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2 / O43741* / Q6PAM0* / protein kinase, AMP-activated, beta 2 non-catalytic subunit*  / complex
 ENSGALG00000008347 ATG13 / autophagy related 13 / O75143* / Q91YI1* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / complex / reaction
 ENSGALG00000015259 RB1CC1 / RB1 inducible coiled-coil 1 / Q8TDY2* / Q9ESK9* / RB1-inducible coiled-coil protein 1 *  / complex / reaction
 ENSGALG00000003339 MTOR / mechanistic target of rapamycin kinase / P42345* / Q9JLN9* / Serine/threonine-protein kinase mTOR *  / reaction
 ENSGALG00000014712 SLC38A9 / solute carrier family 38 member 9 / Q8BGD6* / Q8NBW4* / Sodium-coupled neutral amino acid transporter 9 *  / reaction
 ENSGALG00000012148 ATG14 / autophagy related 14 / Q6ZNE5* / Q8CDJ3* / Beclin 1-associated autophagy-related key regulator *  / reaction
 ENSGALG00000005522 DYNLL2 / dynein light chain LC8-type 2 / Q96FJ2* / Q9D0M5* / Dynein light chain 2, cytoplasmic *  / reaction
 ENSGALG00000026971 RRAGD / Ras related GTP binding D / Q9NQL2*  / reaction
 ENSGALG00000011360 PRKAG3 / 5-AMP-activated protein kinase subunit gamma-3 / Q9UGI9* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-activated, gamma 3 non-catat...  / complex
 ENSGALG00000041226 RRAGB* / RRAGA* / Q7L523* / Q80X95* / Q5VZM2* / Q6NTA4* / Ras related GTP binding A* / Ras related GTP binding B* / Ras-related GTP-binding protein A * / Ras-related GTP-binding protein B *  / reaction
 ENSGALG00000005646 TSC2 / TSC complex subunit 2 / P49815* / tuberous sclerosis 2*  / reaction
 ENSGALG00000036282 O54950* / P54619* / PRKAG1* / protein kinase AMP-activated non-catalytic subunit gamma 1* / protein kinase, AMP-activated, gamma 1 non-catalytic subunit*  / complex
 ENSGALG00000020999 DYNLL1 / dynein light chain LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / reaction
 ENSGALG00000007373 PRKAB1 / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-activated, beta 1 non-catalytic subunit*  / complex
 ENSGALG00000035773 PIK3C3 / phosphatidylinositol 3-kinase catalytic subunit type 3 / Q6PF93* / Q8NEB9*  / reaction
 ENSGALG00000005878 MLST8 / MTOR associated protein, LST8 homolog / Q9BVC4* / Q9DCJ1* / Target of rapamycin complex subunit LST8 *  / reaction
 ENSGALG00000011917 PPM1A / protein phosphatase, Mg2+/Mn2+ dependent 1A / P35813* / P49443* / protein phosphatase 1A, magnesium dependent, alpha isoform*  / reaction
 ENSGALG00000040008 STK11 / Q0GGW5 / Serine/threonine-protein kinase STK11 / Q9WTK7* / Q15831* / serine/threonine kinase 11*  / reaction






 

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