ENSDARG00000060641


Danio rerio

Features
Gene ID: ENSDARG00000060641
  
Biological name :prkaa2
  
Synonyms : prkaa2 / protein kinase, AMP-activated, alpha 2 catalytic subunit
  
Possible biological names infered from orthology : P54646 / protein kinase AMP-activated catalytic subunit alpha 2 / Q8BRK8
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 8028613
Gene end: 8067973
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080103
NCBI entrez gene - 572074     See in Manteia.
swissprot - E7F9C4
ZFIN ID - ZDB-GENE-081120-5
Ensembl - ENSDARG00000060641
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKAA2ENSGALG00000010826Gallus gallus
 P54646ENSG00000162409Homo sapiens
 Prkaa2ENSMUSG00000028518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkaa1 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / Q5EG47* / protein kinase AMP-activated catalytic subunit alpha 1*ENSDARG0000006059675
nuak1a / NUAK family, SNF1-like kinase, 1a / NUAK1* / Q641K5* / O60285* / NUAK family kinase 1* / NUAK family SNF1-like kinase 1 *ENSDARG0000002008628
nuak1b / NUAK family, SNF1-like kinase, 1b / NUAK1* / Q641K5* / O60285* / NUAK family kinase 1* / NUAK family SNF1-like kinase 1 *ENSDARG0000002867627
nuak2 / NUAK family, SNF1-like kinase, 2 / Q8BZN4* / Q9H093* / NUAK family kinase 2*ENSDARG0000006366126
si:ch211-117c9.1ENSDARG0000009017922
trib3 / tribbles pseudokinase 3 / Q8K4K2* / Q96RU7* / Tribbles homolog 3 *ENSDARG0000001620016
trib1 / tribbles pseudokinase 1 / Q96RU8*ENSDARG0000011096313
stk40 / serine/threonine kinase 40 / Q8N2I9*ENSDARG0000009813512
trib2 / tribbles pseudokinase 2 / Q92519*ENSDARG0000006817911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR032270  AMPK, C-terminal adenylate sensor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035404 histone-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042149 cellular response to glucose starvation IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004679 AMP-activated protein kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035174 histone serine kinase activity IBA


Pathways (from Reactome)
Pathway description
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
Import of palmitoyl-CoA into the mitochondrial matrix
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017537 prkag3a / protein kinase, AMP-activated, gamma 3a non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / complex
 ENSDARG00000003818 prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / O54950* / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / complex
 ENSDARG00000046143 prkab1b / protein kinase, AMP-activated, beta 1 non-catalytic subunit, b / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / complex
 ENSDARG00000036040 atg13 / Q7SYE0 / ATG13 autophagy related 13 homolog (S. cerevisiae) / Q91YI1* / O75143* / autophagy related 13* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / reaction / complex
 ENSDARG00000043287 atg101 / Q3B736 / autophagy related 101 / Q9BSB4* / Q9D8Z6* / Autophagy-related protein 101 *  / complex / reaction
 ENSDARG00000074481 ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*  / reaction / complex
 ENSDARG00000054829 pik3c3 / phosphatidylinositol 3-kinase, catalytic subunit type 3 / Q6PF93* / Q8NEB9*  / reaction
 ENSDARG00000002670 ATG14 / zgc:113944 / Q6ZNE5* / Q8CDJ3* / autophagy related 14* / Beclin 1-associated autophagy-related key regulator *  / reaction
 ENSDARG00000067817 CABZ01083448.1 / O43741* / PRKAB2* / protein kinase AMP-activated non-catalytic subunit beta 2*  / complex
 ENSDARG00000060469 pik3r4 / phosphoinositide-3-kinase, regulatory subunit 4 / Q8VD65* / Q99570*  / reaction
 ENSDARG00000079128 becn1 / F1RCP1 / beclin 1, autophagy related / BECN2* / Q14457* / O88597* / P0DM65* / A8MW95* / Gm38100* / beclin 2* / beclin 1* / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa*  / reaction
 ENSDARG00000070012 sesn2 / sestrin 2 / P58004* / P58043*  / reaction / complex
 ENSDARG00000020693 sesn1 / sestrin 1 / P58006* / Q9Y6P5*  / complex / reaction
 ENSDARG00000003167 mlst8 / Q803V5 / MTOR associated protein, LST8 homolog (S. cerevisiae) / Q9BVC4* / Q9DCJ1* / MTOR associated protein, LST8 homolog* / Target of rapamycin complex subunit LST8 *  / reaction
 ENSDARG00000058454 dynll1 / dynein, light chain, LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / reaction
 ENSDARG00000076559 rb1cc1 / RB1-inducible coiled-coil 1 / Q8TDY2*  / reaction / complex
 ENSDARG00000032769 Q08BA4 / slc38a9 / solute carrier family 38, member 9 / Q8NBW4*  / reaction
 ENSDARG00000098726 rptor / regulatory associated protein of MTOR, complex 1 / Q8N122*  / reaction
 ENSDARG00000069790 dynll2a / dynein, light chain, LC8-type 2a / Q9D0M5* / DYNLL2* / Q96FJ2* / dynein light chain LC8-type 2* / Dynein light chain 2, cytoplasmic *  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000000369 prkag3b / protein kinase, AMP-activated, gamma 3b non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / complex
 ENSDARG00000044183 prkab1a / protein kinase, AMP-activated, beta 1 non-catalytic subunit, a / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / complex






 

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