ENSDARG00000016200


Danio rerio

Features
Gene ID: ENSDARG00000016200
  
Biological name :trib3
  
Synonyms : trib3 / tribbles pseudokinase 3
  
Possible biological names infered from orthology : Q8K4K2 / Q96RU7 / Tribbles homolog 3
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 24058530
Gene end: 24063196
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000036401
NCBI entrez gene - 405805     See in Manteia.
RefSeq - NM_212869
RefSeq Peptide - NP_998034
swissprot - F1QCV8
ZFIN ID - ZDB-GENE-040426-2609
Ensembl - ENSDARG00000016200
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRIB3ENSG00000101255Homo sapiens
 Trib3ENSMUSG00000032715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
trib1 / tribbles pseudokinase 1 / Q96RU8*ENSDARG0000011096343
trib2 / tribbles pseudokinase 2 / Q92519*ENSDARG0000006817935
nuak1a / NUAK family, SNF1-like kinase, 1a / NUAK1* / Q641K5* / O60285* / NUAK family kinase 1* / NUAK family SNF1-like kinase 1 *ENSDARG0000002008626
nuak1b / NUAK family, SNF1-like kinase, 1b / NUAK1* / Q641K5* / O60285* / NUAK family kinase 1* / NUAK family SNF1-like kinase 1 *ENSDARG0000002867625
prkaa2 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSDARG0000006064125
nuak2 / NUAK family, SNF1-like kinase, 2 / Q8BZN4* / Q9H093* / NUAK family kinase 2*ENSDARG0000006366124
si:ch211-117c9.1ENSDARG0000009017923
stk40 / serine/threonine kinase 40 / Q8N2I9*ENSDARG0000009813523
prkaa1 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / Q5EG47* / protein kinase AMP-activated catalytic subunit alpha 1*ENSDARG0000006059623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR024104  Pseudokinase tribbles family/serine-threonine-protein kinase 40
 IPR024106  Pseudokinase tribbles, TRB3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043405 regulation of MAP kinase activity IBA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Activation of AKT2
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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