ENSDARG00000060596


Danio rerio

Features
Gene ID: ENSDARG00000060596
  
Biological name :prkaa1
  
Synonyms : prkaa1 / protein kinase, AMP-activated, alpha 1 catalytic subunit
  
Possible biological names infered from orthology : protein kinase AMP-activated catalytic subunit alpha 1 / Q13131 / Q5EG47
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 33238545
Gene end: 33255759
  
Corresponding Affymetrix probe sets: Dr.1297.1.A1_at (Zebrafish Array)   Dr.13337.1.A1_at (Zebrafish Array)   Dr.24306.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000079966
NCBI entrez gene - 100001198     See in Manteia.
swissprot - A5WUM0
ZFIN ID - ZDB-GENE-030325-1
Ensembl - ENSDARG00000060596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKAA1ENSGALG00000014832Gallus gallus
 PRKAA1ENSG00000132356Homo sapiens
 Prkaa1ENSMUSG00000050697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkaa2 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSDARG0000006064172
nuak1a / NUAK family, SNF1-like kinase, 1a / NUAK1* / Q641K5* / O60285* / NUAK family kinase 1* / NUAK family SNF1-like kinase 1 *ENSDARG0000002008627
nuak1b / NUAK family, SNF1-like kinase, 1b / NUAK1* / Q641K5* / O60285* / NUAK family kinase 1* / NUAK family SNF1-like kinase 1 *ENSDARG0000002867626
nuak2 / NUAK family, SNF1-like kinase, 2 / Q8BZN4* / Q9H093* / NUAK family kinase 2*ENSDARG0000006366124
si:ch211-117c9.1ENSDARG0000009017920
trib3 / tribbles pseudokinase 3 / Q8K4K2* / Q96RU7* / Tribbles homolog 3 *ENSDARG0000001620014
stk40 / serine/threonine kinase 40 / Q8N2I9*ENSDARG0000009813512
trib1 / tribbles pseudokinase 1 / Q96RU8*ENSDARG0000011096312
trib2 / tribbles pseudokinase 2 / Q92519*ENSDARG0000006817911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR032270  AMPK, C-terminal adenylate sensor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:1990787 negative regulation of hh target transcription factor activity IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017537 prkag3a / protein kinase, AMP-activated, gamma 3a non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / complex
 ENSDARG00000003818 prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / O54950* / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / complex
 ENSDARG00000046143 prkab1b / protein kinase, AMP-activated, beta 1 non-catalytic subunit, b / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / complex
 ENSDARG00000036040 atg13 / Q7SYE0 / ATG13 autophagy related 13 homolog (S. cerevisiae) / Q91YI1* / O75143* / autophagy related 13* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / reaction / complex
 ENSDARG00000032769 Q08BA4 / slc38a9 / solute carrier family 38, member 9 / Q8NBW4*  / reaction
 ENSDARG00000079128 becn1 / F1RCP1 / beclin 1, autophagy related / BECN2* / Q14457* / O88597* / P0DM65* / A8MW95* / Gm38100* / beclin 2* / beclin 1* / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa*  / reaction
 ENSDARG00000070012 sesn2 / sestrin 2 / P58004* / P58043*  / complex / reaction
 ENSDARG00000098726 rptor / regulatory associated protein of MTOR, complex 1 / Q8N122*  / reaction
 ENSDARG00000058454 dynll1 / dynein, light chain, LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / reaction
 ENSDARG00000003167 mlst8 / Q803V5 / MTOR associated protein, LST8 homolog (S. cerevisiae) / Q9BVC4* / Q9DCJ1* / MTOR associated protein, LST8 homolog* / Target of rapamycin complex subunit LST8 *  / reaction
 ENSDARG00000069790 dynll2a / dynein, light chain, LC8-type 2a / Q9D0M5* / DYNLL2* / Q96FJ2* / dynein light chain LC8-type 2* / Dynein light chain 2, cytoplasmic *  / reaction
 ENSDARG00000054829 pik3c3 / phosphatidylinositol 3-kinase, catalytic subunit type 3 / Q6PF93* / Q8NEB9*  / reaction
 ENSDARG00000043287 atg101 / Q3B736 / autophagy related 101 / Q9BSB4* / Q9D8Z6* / Autophagy-related protein 101 *  / reaction / complex
 ENSDARG00000074481 ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*  / reaction / complex
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000060469 pik3r4 / phosphoinositide-3-kinase, regulatory subunit 4 / Q8VD65* / Q99570*  / reaction
 ENSDARG00000002670 ATG14 / zgc:113944 / Q6ZNE5* / Q8CDJ3* / autophagy related 14* / Beclin 1-associated autophagy-related key regulator *  / reaction
 ENSDARG00000000369 prkag3b / protein kinase, AMP-activated, gamma 3b non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / complex
 ENSDARG00000020693 sesn1 / sestrin 1 / P58006* / Q9Y6P5*  / complex / reaction
 ENSDARG00000076559 rb1cc1 / RB1-inducible coiled-coil 1 / Q8TDY2*  / reaction / complex
 ENSDARG00000044183 prkab1a / protein kinase, AMP-activated, beta 1 non-catalytic subunit, a / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / complex
 ENSDARG00000067817 CABZ01083448.1 / O43741* / PRKAB2* / protein kinase AMP-activated non-catalytic subunit beta 2*  / complex






 

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