ENSDARG00000074481


Danio rerio

Features
Gene ID: ENSDARG00000074481
  
Biological name :ulk1b
  
Synonyms : ulk1b / unc-51 like autophagy activating kinase 1
  
Possible biological names infered from orthology : O75385 / ULK1 / unc-51 like kinase 1
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 14839589
Gene end: 14878220
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000113763
NCBI entrez gene - 558848     See in Manteia.
swissprot - E9QIB7
ZFIN ID - ZDB-GENE-071203-2
Ensembl - ENSDARG00000074481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ULK1ENSGALG00000002403Gallus gallus
 ULK1ENSG00000177169Homo sapiens
 Ulk1ENSMUSG00000029512Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ulk1a / unc-51 like autophagy activating kinase 1a / ULK1* / O75385* / unc-51 like kinase 1* / unc-51 like autophagy activating kinase 1*ENSDARG0000006251852
ulk2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSDARG0000009720551
ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSDARG0000007912314
chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSDARG0000001166213
tbk1 / TANK-binding kinase 1 / Q9UHD2*ENSDARG0000010309512
ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*ENSDARG0000007060612
ulk3 / unc-51 like kinase 3 / Q6PHR2*ENSDARG0000010166110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022708  Serine/threonine-protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0048675 axon extension IBA
 cellular_componentGO:1990316 Atg1/ULK1 kinase complex IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003167 mlst8 / Q803V5 / MTOR associated protein, LST8 homolog (S. cerevisiae) / Q9BVC4* / Q9DCJ1* / MTOR associated protein, LST8 homolog* / Target of rapamycin complex subunit LST8 *  / complex / reaction
 ENSDARG00000017537 prkag3a / protein kinase, AMP-activated, gamma 3a non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / reaction / complex
 ENSDARG00000003818 prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / O54950* / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction / complex
 ENSDARG00000032769 Q08BA4 / slc38a9 / solute carrier family 38, member 9 / Q8NBW4*  / complex / reaction
 ENSDARG00000046143 prkab1b / protein kinase, AMP-activated, beta 1 non-catalytic subunit, b / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / reaction / complex
 ENSDARG00000036040 atg13 / Q7SYE0 / ATG13 autophagy related 13 homolog (S. cerevisiae) / Q91YI1* / O75143* / autophagy related 13* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / complex
 ENSDARG00000003520 tbc1d14 / TBC1 domain family, member 14 / Q9P2M4*  / complex / reaction
 ENSDARG00000060596 prkaa1 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / Q5EG47* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction / complex
 ENSDARG00000043287 atg101 / Q3B736 / autophagy related 101 / Q9BSB4* / Q9D8Z6* / Autophagy-related protein 101 *  / complex
 ENSDARG00000060641 prkaa2 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction / complex
 ENSDARG00000044183 prkab1a / protein kinase, AMP-activated, beta 1 non-catalytic subunit, a / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / reaction / complex
 ENSDARG00000076559 rb1cc1 / RB1-inducible coiled-coil 1 / Q8TDY2*  / complex
 ENSDARG00000067817 CABZ01083448.1 / O43741* / PRKAB2* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction / complex
 ENSDARG00000000369 prkag3b / protein kinase, AMP-activated, gamma 3b non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / reaction / complex
 ENSDARG00000098726 rptor / regulatory associated protein of MTOR, complex 1 / Q8N122*  / complex / reaction
 ENSDARG00000041878 rab11ba / RAB11B, member RAS oncogene family, a / RAB11B* / P46638* / Q15907* / RAB11B, member RAS oncogene family*  / complex / reaction
 ENSDARG00000060469 pik3r4 / phosphoinositide-3-kinase, regulatory subunit 4 / Q8VD65* / Q99570*  / reaction
 ENSDARG00000079128 becn1 / F1RCP1 / beclin 1, autophagy related / BECN2* / Q14457* / O88597* / P0DM65* / A8MW95* / Gm38100* / beclin 2* / beclin 1* / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa*  / reaction
 ENSDARG00000040822 fundc1 / Q6DH87 / FUN14 domain containing 1 / Q9DB70* / Q8IVP5* / FUN14 domain-containing protein 1 *  / reaction
 ENSDARG00000054829 pik3c3 / phosphatidylinositol 3-kinase, catalytic subunit type 3 / Q6PF93* / Q8NEB9*  / reaction
 ENSDARG00000058454 dynll1 / dynein, light chain, LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / reaction
 ENSDARG00000069790 dynll2a / dynein, light chain, LC8-type 2a / Q9D0M5* / DYNLL2* / Q96FJ2* / dynein light chain LC8-type 2* / Dynein light chain 2, cytoplasmic *  / reaction
 ENSDARG00000090086 rab11bb / RAB11B, member RAS oncogene family, b / RAB11B* / P46638* / Q15907* / RAB11B, member RAS oncogene family*  / reaction / complex
 ENSDARG00000002670 ATG14 / zgc:113944 / Q6ZNE5* / Q8CDJ3* / autophagy related 14* / Beclin 1-associated autophagy-related key regulator *  / reaction






 

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