ENSDARG00000011662


Danio rerio

Features
Gene ID: ENSDARG00000011662
  
Biological name :chuk
  
Synonyms : chuk / conserved helix-loop-helix ubiquitous kinase
  
Possible biological names infered from orthology : O15111
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 25286538
Gene end: 25379820
  
Corresponding Affymetrix probe sets: Dr.14012.1.S1_at (Zebrafish Array)   NM_200317_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000147043
Ensembl peptide - ENSDARP00000153722
Ensembl peptide - ENSDARP00000013115
NCBI entrez gene - 393287     See in Manteia.
RefSeq - NM_200317
RefSeq Peptide - NP_956611
swissprot - B8JIH4
ZFIN ID - ZDB-GENE-040426-1069
Ensembl - ENSDARG00000011662
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHUKENSGALG00000003289Gallus gallus
 CHUKENSG00000213341Homo sapiens
 ChukENSMUSG00000025199Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSDARG0000007912347
tbk1 / TANK-binding kinase 1 / Q9UHD2*ENSDARG0000010309520
ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*ENSDARG0000007060618
ulk2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSDARG0000009720518
ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*ENSDARG0000007448117
ulk1a / unc-51 like autophagy activating kinase 1a / ULK1* / O75385* / unc-51 like kinase 1* / unc-51 like autophagy activating kinase 1*ENSDARG0000006251816
ulk3 / unc-51 like kinase 3 / Q6PHR2*ENSDARG000001016618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022007  I-kappa-kinase-beta NEMO binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000086 EVL EVL increased permeability , abnormal
EVL actin filament disorganized , abnormal
EVL moderately well differentiated , abnormal
EVL bicellular tight junction irregular spatial pattern , abnormal
EVL cell junction immature , abnormal
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 ZFA:0000711 DEL DEL extracellular space decreased area , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr