ENSGALG00000003289


Gallus gallus

Features
Gene ID: ENSGALG00000003289
  
Biological name :CHUK
  
Synonyms : CHUK / inhibitor of nuclear factor kappa-B kinase subunit alpha
  
Possible biological names infered from orthology : conserved helix-loop-helix ubiquitous kinase / O15111
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 9321757
Gene end: 9344610
  
Corresponding Affymetrix probe sets: Gga.5483.1.S1_s_at (Chicken Array)   GgaAffx.2058.1.S1_at (Chicken Array)   GgaAffx.2058.1.S1_s_at (Chicken Array)   GgaAffx.2058.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051589
Ensembl peptide - ENSGALP00000005196
NCBI entrez gene - 423669     See in Manteia.
RefSeq - XM_015278675
RefSeq - NM_001012904
RefSeq Peptide - NP_001012922
swissprot - A0A1D5PFM2
swissprot - F1NLD4
Ensembl - ENSGALG00000003289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chukENSDARG00000011662Danio rerio
 CHUKENSG00000213341Homo sapiens
 ChukENSMUSG00000025199Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IKBKB / inhibitor of nuclear factor kappa B kinase subunit beta / O14920* / inhibitor of kappaB kinase beta*ENSGALG0000003183237
TBK1 / TANK binding kinase 1 / Q9UHD2* / Q9WUN2*ENSGALG0000000984019
ULK2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSGALG0000000472719
ULK1 / unc-51 like autophagy activating kinase 1 / O75385* / unc-51 like kinase 1*ENSGALG0000000240318
IKBKE / inhibitor of nuclear factor kappa B kinase subunit epsilon / Q14164* / Q9R0T8*ENSGALG0000001335617
ULK3 / unc-51 like kinase 3 / Q3U3Q1* / Q6PHR2*ENSGALG0000003221511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022007  I-kappa-kinase-beta NEMO binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the cytosol
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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