ENSMUSG00000025199


Mus musculus

Features
Gene ID: ENSMUSG00000025199
  
Biological name :Chuk
  
Synonyms : Chuk / conserved helix-loop-helix ubiquitous kinase
  
Possible biological names infered from orthology : O15111
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 44073335
Gene end: 44107480
  
Corresponding Affymetrix probe sets: 10467921 (MoGene1.0st)   1417091_at (Mouse Genome 430 2.0 Array)   1428210_s_at (Mouse Genome 430 2.0 Array)   1451383_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026217
Ensembl peptide - ENSMUSP00000113809
NCBI entrez gene - 12675     See in Manteia.
MGI - MGI:99484
RefSeq - NM_007700
RefSeq - NM_001162410
RefSeq - XM_011247129
RefSeq Peptide - NP_001155882
RefSeq Peptide - NP_031726
swissprot - E9QNL4
swissprot - E9Q605
Ensembl - ENSMUSG00000025199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chukENSDARG00000011662Danio rerio
 CHUKENSGALG00000003289Gallus gallus
 CHUKENSG00000213341Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ikbkb / inhibitor of kappaB kinase beta / O14920* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSMUSG0000003153750
Ulk2 / Q9QY01 / unc-51 like kinase 2 / Q8IYT8* / unc-51 like autophagy activating kinase 2*ENSMUSG0000000479821
Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*ENSMUSG0000002951219
Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*ENSMUSG0000004234919
Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*ENSMUSG0000002011517
Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*ENSMUSG0000003230811


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR022007  I-kappa-kinase-beta NEMO binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003009 skeletal muscle contraction IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010034 response to acetate IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008385 IkappaB kinase complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000098 abnormal vomer bone morphology "missing triangular flat bone of the nasal septum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfrtm1Mag,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: B6.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: FVB.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrwa2/Egfrwa2,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001230 epidermal desquamation "shedding of the cuticle of the epidermis in scales or shreds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0001241 absent cornified layer "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001310 abnormal conjunctiva morphology "malformation or atrophy of the mucous membrane that lines the inner surface of the eyelids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrwa2/Egfrwa2,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Chuktm2Yhu/Chuktm2Yhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfrtm1Mag,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb1tm1Bal Tg(Tnfsf13b)1Fma

Allelic Composition: Chuktm1Mka/Chuktm1Mka
Genetic Background: B6.129-Chuktm1Mka

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003142 anotia "congenital absence of one or both auricles of the ears" [J:57313, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003276 esophageal atresia "congenital blockage or absence of the lumen of the esophagus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004379 wide frontal bone "increased width of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004418 small parietal bone "reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004448 abnormal presphenoid bone morphology "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

 MP:0004546 esophagus hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004574 broad limb buds "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004622 sacral vertebral fusion "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004657 small sacral vertebrae "reduced size of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Mka/Chuktm1Mka,Irf6tm1Mjd/Irf6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Mka/Chuk+,Irf6tm1Mjd/Irf6tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008717 lung squamous cell carcinoma "a lung carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Lex/Chuktm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Lex/Chuktm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0008991 abnormal bile canaliculus morphology "any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009343 dilated gall bladder "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0009560 absent epidermis stratum granulosum "absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm2Yhu/Chuktm2Yhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010234 abnormal vibrissa follicle morphology "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010799 stomach mucosa hyperplasia "overdevelopment or increased size, usually due to an increase in the number of cells, of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010864 abnormal enamel knot morphology "any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8808404]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010880 small esophagus "reduced size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: B6.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Tg(KRT5-cre)5132Jlj/0
Genetic Background: FVB.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfrtm1Mag,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Aki/Chuktm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chuktm1Mpa/Chuktm1Mpa,Tg(KRT14-cre)1Cgn/?
Genetic Background: involves: C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Chuktm1.1Mpa/Chuktm1.1Mpa
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0011706 abnormal fibroblast migration "any anomaly of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [GO:0010761]
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Allelic Composition: Chuktm1Lex/Chuktm1Lex,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S/SvEvBrd * C57BL/6

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Chuktm1Lex/Chuktm1Lex,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S/SvEvBrd * C57BL/6

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012279 wide sternum "an increase in the width of the long flat bone of the chest that articulates with the clavicle and first seven rib pairs" [MGI:anna]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver,Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020416 decreased fibroblast chemotaxis "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695]
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Allelic Composition: Chuktm1Lex/Chuktm1Lex,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S/SvEvBrd * C57BL/6

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030197 small nasal septum "reduced size of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [MGI:anna]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030266 small vomer bone "reduced size of the triangular flat bone of the nasal septum" [MGI:anna]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000020372 Rack1 / P68040 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed / P63244* / receptor for activated C kinase 1*  / complex / reaction
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / reaction
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000047098 Rnf31 / Q924T7 / E3 ubiquitin-protein ligase RNF31 / Q96EP0* / AL136295.5* / ring finger protein 31*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000027466 Rbck1 / Q9WUB0 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / RANBP2-type and C3HC4-type zinc finger containing 1*  / reaction / complex
 ENSMUSG00000022552 Q91WA6 / Sharpin / Q9H0F6* / SHANK associated RH domain interactor*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / reaction
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / reaction / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex / reaction
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex
 ENSMUSG00000020275 Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*  / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction
 ENSMUSG00000002983 Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSMUSG00000025225 Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*  / complex / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
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