ENSMUSG00000039005


Mus musculus

Features
Gene ID: ENSMUSG00000039005
  
Biological name :Tlr4
  
Synonyms : Q9QUK6 / Tlr4 / toll-like receptor 4
  
Possible biological names infered from orthology : O00206
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C1
Gene start: 66827584
Gene end: 66930284
  
Corresponding Affymetrix probe sets: 10505517 (MoGene1.0st)   1418162_at (Mouse Genome 430 2.0 Array)   1418163_at (Mouse Genome 430 2.0 Array)   1430695_at (Mouse Genome 430 2.0 Array)   1442827_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102988
Ensembl peptide - ENSMUSP00000045770
NCBI entrez gene - 21898     See in Manteia.
MGI - MGI:96824
RefSeq - NM_021297
RefSeq Peptide - NP_067272
swissprot - Q9QUK6
swissprot - A2BHU8
swissprot - L0CL36
Ensembl - ENSMUSG00000039005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr4alENSDARG00000075671Danio rerio
 tlr4baENSDARG00000019742Danio rerio
 tlr4bbENSDARG00000022048Danio rerio
 TLR4ENSGALG00000007001Gallus gallus
 TLR4ENSG00000136869Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052224
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377724
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458323
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532222
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163922
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149821
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799521
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916421
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482720
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027168  Toll-like receptor 4
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002322 B cell proliferation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002537 nitric oxide production involved in inflammatory response IMP
 biological_processGO:0002730 regulation of dendritic cell cytokine production IDA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity NAS
 biological_processGO:0007252 I-kappaB phosphorylation ISO
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0010572 positive regulation of platelet activation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0032497 detection of lipopolysaccharide TAS
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032700 negative regulation of interleukin-17 production IMP
 biological_processGO:0032707 negative regulation of interleukin-23 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032727 positive regulation of interferon-alpha production IDA
 biological_processGO:0032728 positive regulation of interferon-beta production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032732 positive regulation of interleukin-1 production IDA
 biological_processGO:0032733 positive regulation of interleukin-10 production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production NAS
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IDA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway IGI
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process ISO
 biological_processGO:0043032 positive regulation of macrophage activation IGI
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IMP
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IMP
 biological_processGO:0045362 positive regulation of interleukin-1 biosynthetic process NAS
 biological_processGO:0045368 positive regulation of interleukin-13 biosynthetic process NAS
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process NAS
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IGI
 biological_processGO:0045576 mast cell activation NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IMP
 biological_processGO:0050702 interleukin-1 beta secretion IDA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISO
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050729 positive regulation of inflammatory response IGI
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IDA
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 biological_processGO:0060907 positive regulation of macrophage cytokine production IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
 biological_processGO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus IGI
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IGI
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly IDA
 biological_processGO:1903223 positive regulation of oxidative stress-induced neuron death IGI
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IMP
 biological_processGO:1904646 cellular response to amyloid-beta ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISO
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0046696 lipopolysaccharide receptor complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0001530 lipopolysaccharide binding IBA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Regulation of TLR by endogenous ligand
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Mc1rE-so/Mc1r+
Genetic Background: C3H

Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0000316 cellular necrosis "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ticam1M2Btlr/Ticam1+
Genetic Background: C57BL/6J-Ticam1M2Btlr

Allelic Composition: Tlr4lps-7Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11+,Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4lps-del/Tlr4lps-del,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4lps-del/Tlr4lps-del,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kittm1Bpr/Kittm1Bpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Bmp7tm3(Bmp7)Rob/Bmp7tm2Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tlr4tm1Aki/Tlr4lps-2J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pde6ccpfl1/Pde6ccpfl1
Genetic Background: B6.CXB1-Pde6ccpfl1

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0002271 abnormal alveolar duct morphology "any structural anomaly of the conducting tubes leading to the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002319 hyperoxia "elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tsc1tm1.1Djk/Tsc1+
Genetic Background: either: 129S4/SvJae-Tsc1tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki,Tlr5tm1Flv/Tlr5tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr4lps-Btlr/Tlr4lps-Btlr
Genetic Background: C57BL/6J-Tlr4lps-Btlr

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kittm1Bpr/Kittm1Bpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Npc1m1N/Npc1m1N,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4lps-del/Tlr4lps-del,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Pglyrp1tm1Rdz/Pglyrp1tm1Rdz,Pglyrp2tm1Rdz/Pglyrp2tm1Rdz
Genetic Background: C.129S-Pglyrp1tm1Rdz Pglyrp2tm1Rdz

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Tlr4tm1Djh/Tlr4tm1Djh,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0003795 abnormal bone structure 
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Allelic Composition: Mc1rE-so/Mc1r+
Genetic Background: C3H

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0003948 abnormal gas homeostasis "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0004130 abnormal muscle cell glucose uptake "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C.C3-Tlr4Lps-d/J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1Djh/Tlr4tm1Djh,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde6ccpfl1/Pde6ccpfl1
Genetic Background: B6.CXB1-Pde6ccpfl1

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0004951 abnormal spleen weight "anomaly in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Tlr4lps-5Btlr/Tlr4lps-5Btlr
Genetic Background: C57BL/6J-Tlr4lps-5Btlr

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Pde6ccpfl1/Pde6ccpfl1
Genetic Background: B6.CXB1-Pde6ccpfl1

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tlr4tm1Djh/Tlr4tm1Djh,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11+,Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pde6ccpfl1/Pde6ccpfl1
Genetic Background: B6.CXB1-Pde6ccpfl1

 MP:0005340 altered susceptibility to atherosclerosis "a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Mc1rE-so/Mc1r+
Genetic Background: C3H

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc1rE-so/Mc1r+
Genetic Background: C3H

Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0005667 abnormal circulating leptin level "aberrant blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0006080 CNS ischemia "abnormal incidence of or response to loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0008251 abnormal phagocyte morphology "any structural anomaly of cells capable of ingesting particulate matter via phagocytosis" [CL:0000234, ISBN:0721601464]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

Allelic Composition: Tlr4Lps-2Btlr/?
Genetic Background: C57BL/6J-Tlr4Lps-2Btlr

Allelic Composition: Tlr4Lps-3Btlr/Tlr4Lps-3Btlr
Genetic Background: C57BL/6J-Tlr4Lps-3Btlr

Allelic Composition: Tlr4Lps-3Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-3Btlr

Allelic Composition: Tlr4lps-4Btlr/Tlr4lps-4Btlr
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

Allelic Composition: Tlr4lps-5Btlr/Tlr4lps-5Btlr
Genetic Background: C57BL/6J-Tlr4lps-5Btlr

Allelic Composition: Tlr4Lps-6Btlr/Tlr4Lps-6Btlr
Genetic Background: C57BL/6J-Tlr4Lps-6Btlr

Allelic Composition: Tlr4Lps-6Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-6Btlr

Allelic Composition: Tlr4lps-7Btlr/Tlr4lps-7Btlr
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4lps-7Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Tlr4Lps-3Btlr/Tlr4Lps-3Btlr
Genetic Background: C57BL/6J-Tlr4Lps-3Btlr

Allelic Composition: Tlr4Lps-3Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-3Btlr

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Nelfbtm1.2Roli/Nelfbtm1.2Roli,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Tlr4lps-7Btlr/Tlr4lps-7Btlr
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4lps-7Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008729 decreased memory B cell number "reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-5Btlr/Tlr4lps-5Btlr
Genetic Background: C57BL/6J-Tlr4lps-5Btlr

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.Cg-Tlr2tm1Kir Tlr4Lps-d

Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0009878 decreased susceptibility to bone fracture "reduced probability that injury or disease will result in damaged or broken bones" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C.C3-Tlr4Lps-d/J

Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScN

 MP:0010159 abnormal enterocyte differentiation "abnormal formation of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0010170 abnormal glial cell apoptosis "change in the timing or the number of glial cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0010908 dilated pulmonary alveolar ducts "expansion or widening of the lumens of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3H/HeJ-Tlr4Lps-d

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4lps-4Btlr
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

Allelic Composition: Tlr4lps-4Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

Allelic Composition: Tlr4lps-5Btlr/Tlr4lps-5Btlr
Genetic Background: C57BL/6J-Tlr4lps-5Btlr

Allelic Composition: Tlr4Lps-6Btlr/Tlr4Lps-6Btlr
Genetic Background: C57BL/6J-Tlr4Lps-6Btlr

Allelic Composition: Tlr4Lps-6Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-6Btlr

Allelic Composition: Tlr4lps-7Btlr/Tlr4lps-7Btlr
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4lps-7Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-4Btlr/Tlr4lps-4Btlr
Genetic Background: C57BL/6J-Tlr4lps-4Btlr

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11+,Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011350 abnormal proximal convoluted tubule brush border morphology "any structural anomaly of the densely packed microvilli that cover the luminal surface of epithelial cells of the proximal convoluted tubule; microvilli increase the luminal surface area of cells, sense the fluid flow in the tubule lumen and convert this information via biochemical responses into reabsorption" [MGI:anna]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129P2-Tlr4tm1Aki

 MP:0011702 abnormal fibroblast proliferation "anomaly in the ability of the a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Tlr4lps-7Btlr/Tlr4lps-7Btlr
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4lps-7Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-7Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

Allelic Composition: Tlr4Lps-8Btlr/Tlr4+
Genetic Background: C57BL/6J-Tlr4Lps-8Btlr

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: Tg(Vil1-cre)997Gum/?,Tlr4lps-del/Tlr4lps-del,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / reaction / complex
 ENSMUSG00000022221 Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*  / reaction / complex
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / reaction / complex
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000066551 Hmgb1 / P63158 / High mobility group protein B1 / P09429* / high mobility group box 1*  / complex / reaction
 ENSMUSG00000056054 P27005 / S100a8 / S100 calcium binding protein A8 (calgranulin A) / P05109* / S100 calcium binding protein A8*  / reaction / complex
 ENSMUSG00000050132 Sarm1 / Q6PDS3 / Sterile alpha and TIR motif-containing protein 1 / Q6SZW1* / sterile alpha and TIR motif containing 1*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSMUSG00000021795 Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*  / complex / reaction
 ENSMUSG00000051498 Tlr6 / toll-like receptor 6 / Q9Y2C9*  / complex
 ENSMUSG00000044080 S100a1 / S100 calcium binding protein A1 / P23297*  / complex / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / reaction / complex
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / reaction / complex
 ENSMUSG00000056071 P31725 / S100a9 / S100 calcium binding protein A9 (calgranulin B) / P06702* / S100 calcium binding protein A9*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex / reaction
 ENSMUSG00000002944 Cd36 / Q08857 / Platelet glycoprotein 4 / P16671* / CD36 molecule*  / reaction / complex
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000021789 Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / reaction / complex
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / reaction / complex
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / reaction / complex






 

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