ENSMUSG00000003184


Mus musculus

Features
Gene ID: ENSMUSG00000003184
  
Biological name :Irf3
  
Synonyms : interferon regulatory factor 3 / Irf3 / P70671
  
Possible biological names infered from orthology : Q14653
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44997648
Gene end: 45002848
  
Corresponding Affymetrix probe sets: 10552812 (MoGene1.0st)   1416898_a_at (Mouse Genome 430 2.0 Array)   1426111_x_at (Mouse Genome 430 2.0 Array)   1435271_at (Mouse Genome 430 2.0 Array)   1438721_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146383
Ensembl peptide - ENSMUSP00000147187
Ensembl peptide - ENSMUSP00000147175
Ensembl peptide - ENSMUSP00000146773
Ensembl peptide - ENSMUSP00000146729
Ensembl peptide - ENSMUSP00000003284
Ensembl peptide - ENSMUSP00000103465
NCBI entrez gene - 54131     See in Manteia.
MGI - MGI:1859179
RefSeq - XM_006540996
RefSeq - NM_016849
RefSeq - XM_006540995
RefSeq Peptide - NP_058545
swissprot - A0A140LJE8
swissprot - A0A140LJD9
swissprot - Q3U9K6
swissprot - A0A140LI96
swissprot - A0A140LHE6
swissprot - P70671
Ensembl - ENSMUSG00000003184
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf3ENSDARG00000076251Danio rerio
 IRF3ENSG00000126456Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*ENSMUSG0000002549828
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*ENSMUSG0000002977126
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*ENSMUSG0000002135623
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663823
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*ENSMUSG0000004151520
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*ENSMUSG0000000232517
Irf1 / P15314 / interferon regulatory factor 1 / P10914*ENSMUSG0000001889912
Irf2 / P23906 / interferon regulatory factor 2 / P14316*ENSMUSG0000003162712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032727 positive regulation of interferon-alpha production IMP
 biological_processGO:0032728 positive regulation of interferon-beta production TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043330 response to exogenous dsRNA IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045351 type I interferon biosynthetic process IGI
 biological_processGO:0045358 negative regulation of interferon-beta biosynthetic process IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050689 negative regulation of defense response to virus by host IDA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071359 cellular response to dsRNA IEA
 biological_processGO:0097300 programmed necrotic cell death IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
IRF3 mediated activation of type 1 IFN
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfdtm1Mach/Y
Genetic Background: involves: 129S1/Sv

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis5AT161/Themis5AT161
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0008548 abnormal circulating interferon level "anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000032171 Pin1 / Q9QUR7 / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / reaction / complex
 ENSMUSG00000027514 Zbp1 / Q9QY24 / Z-DNA binding protein 1 / Q9H171*  / complex / reaction
 ENSMUSG00000074997 Pin1rt1 / PIN1* / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / reaction / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / complex / reaction
 ENSMUSG00000039982 Dtx4 / Q6PDK8 / E3 ubiquitin-protein ligase DTX4 / Q9Y2E6* / deltex E3 ubiquitin ligase 4*  / complex / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / complex / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction
 ENSMUSG00000024349 Q3TBT3 / Tmem173 / Stimulator of interferons protein / Q86WV6* / transmembrane protein 173*  / complex






 

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