ENSMUSG00000018899


Mus musculus

Features
Gene ID: ENSMUSG00000018899
  
Biological name :Irf1
  
Synonyms : interferon regulatory factor 1 / Irf1 / P15314
  
Possible biological names infered from orthology : P10914
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 53770014
Gene end: 53778374
  
Corresponding Affymetrix probe sets: 10376060 (MoGene1.0st)   1448436_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118795
Ensembl peptide - ENSMUSP00000118314
Ensembl peptide - ENSMUSP00000122101
Ensembl peptide - ENSMUSP00000019043
Ensembl peptide - ENSMUSP00000104548
Ensembl peptide - ENSMUSP00000104550
Ensembl peptide - ENSMUSP00000114315
Ensembl peptide - ENSMUSP00000116656
NCBI entrez gene - 16362     See in Manteia.
MGI - MGI:96590
RefSeq - NM_001159393
RefSeq - NM_001159396
RefSeq - NM_008390
RefSeq Peptide - NP_001152865
RefSeq Peptide - NP_001152868
RefSeq Peptide - NP_032416
swissprot - Q3U5M1
swissprot - Q5SX13
swissprot - Q5SX14
swissprot - D6RH71
swissprot - Q5SX15
swissprot - A8Y5B9
swissprot - Q5SX16
swissprot - P15314
Ensembl - ENSMUSG00000018899
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf1bENSDARG00000043249Danio rerio
 IRF1ENSGALG00000006785Gallus gallus
 IRF1ENSG00000125347Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf2 / P23906 / interferon regulatory factor 2 / P14316*ENSMUSG0000003162739
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*ENSMUSG0000002977122
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663820
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*ENSMUSG0000004151520
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*ENSMUSG0000002135619
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*ENSMUSG0000000232517
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*ENSMUSG0000002549816
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*ENSMUSG0000000318416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR017431  Interferon regulatory factor-1/2
 IPR019817  Interferon regulatory factor, conserved site
 IPR031215  Interferon regulatory factor 1
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002819 regulation of adaptive immune response TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0032728 positive regulation of interferon-beta production ISS
 biological_processGO:0032825 positive regulation of natural killer cell differentiation TAS
 biological_processGO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway IMP
 biological_processGO:0035458 cellular response to interferon-beta ISO
 biological_processGO:0043374 CD8-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045088 regulation of innate immune response TAS
 biological_processGO:0045590 negative regulation of regulatory T cell differentiation IMP
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation TAS
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050776 regulation of immune response IEA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0001573 abnormal circulating alanine transaminase level "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Rag1coln/Rag1coln
Genetic Background: C57BL/6JAnu-Rag1coln/Apb

Allelic Composition: Irf1tm1Mak/Irf1tm1Mak,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Irf1tm1Mak/Irf1tm1Mak,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Irf1M1Btlr/Irf1M1Btlr
Genetic Background: C57BL/6J-Irf1M1Btlr

Allelic Composition: Irf1M1Btlr/Irf1+
Genetic Background: C57BL/6J-Irf1M1Btlr

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002627 teratoma "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irf1tm1Mak/Irf1tm1Mak,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Rag1coln/Rag1coln
Genetic Background: C57BL/6JAnu-Rag1coln/Apb

Allelic Composition: Irf1tm1Mak/Irf1tm1Mak,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0004798 decreased anti-double stranded DNA antibody level "reduced level of antibodies to double stranded DNA present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Irf1M1Btlr/Irf1M1Btlr
Genetic Background: C57BL/6J-Irf1M1Btlr

Allelic Composition: Irf1M1Btlr/Irf1+
Genetic Background: C57BL/6J-Irf1M1Btlr

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Irf1M1Btlr/Irf1M1Btlr
Genetic Background: C57BL/6J-Irf1M1Btlr

Allelic Composition: Irf1M1Btlr/Irf1+
Genetic Background: C57BL/6J-Irf1M1Btlr

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Irf1M1Btlr/Irf1M1Btlr
Genetic Background: C57BL/6J-Irf1M1Btlr

Allelic Composition: Irf1M1Btlr/Irf1+
Genetic Background: C57BL/6J-Irf1M1Btlr

 MP:0008090 increased T-helper 2 cell number "greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Irf1M1Btlr/Irf1M1Btlr
Genetic Background: C57BL/6J-Irf1M1Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Irf1M1Btlr/Irf1M1Btlr
Genetic Background: C57BL/6J-Irf1M1Btlr

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008590 abnormal circulating interleukin-10 level "anomaly in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008600 decreased circulating interleukin-2 level "reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008601 abnormal circulating interleukin-4 level "anomaly in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008608 increased circulating interleukin-13 level "increase in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv

 MP:0008623 increased circulating interleukin-3 level "increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009332 abnormal splenocyte morphology "any structural anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf1tm1Cwe/Irf1tm1Cwe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Irf1tm1Mak/Irf1tm1Mak,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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