ENSMUSG00000031627


Mus musculus

Features
Gene ID: ENSMUSG00000031627
  
Biological name :Irf2
  
Synonyms : interferon regulatory factor 2 / Irf2 / P23906
  
Possible biological names infered from orthology : P14316
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B1.1
Gene start: 46739732
Gene end: 46847458
  
Corresponding Affymetrix probe sets: 10571705 (MoGene1.0st)   1418265_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034041
Ensembl peptide - ENSMUSP00000147318
Ensembl peptide - ENSMUSP00000147279
Ensembl peptide - ENSMUSP00000147138
Ensembl peptide - ENSMUSP00000146992
Ensembl peptide - ENSMUSP00000146714
Ensembl peptide - ENSMUSP00000146495
NCBI entrez gene - 16363     See in Manteia.
MGI - MGI:96591
RefSeq - XM_017312580
RefSeq - NM_008391
RefSeq - XM_006509288
RefSeq - XM_006509289
RefSeq - XM_011242175
RefSeq Peptide - NP_032417
swissprot - A0A1B0GQZ7
swissprot - P23906
swissprot - Q3U2Z2
swissprot - A0A140LJA4
swissprot - A0A140LIX2
swissprot - A0A140LI82
swissprot - A0A1B0GQW5
swissprot - A0A140LHP8
Ensembl - ENSMUSG00000031627
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf2ENSDARG00000040465Danio rerio
 IRF2ENSGALG00000010642Gallus gallus
 IRF2ENSG00000168310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf1 / P15314 / interferon regulatory factor 1 / P10914*ENSMUSG0000001889936
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*ENSMUSG0000002977125
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663822
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*ENSMUSG0000002135622
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*ENSMUSG0000004151522
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*ENSMUSG0000000232517
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*ENSMUSG0000002549816
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*ENSMUSG0000000318415


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR017431  Interferon regulatory factor-1/2
 IPR019817  Interferon regulatory factor, conserved site
 IPR031218  Interferon regulatory factor 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005925 focal adhesion IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sorl1Gt(Ex255)Byg/Sorl1Gt(Ex255)Byg
Genetic Background: B6.129P2-Sorl1Gt(Ex255)Byg

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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