ENSMUSG00000025498


Mus musculus

Features
Gene ID: ENSMUSG00000025498
  
Biological name :Irf7
  
Synonyms : interferon regulatory factor 7 / Irf7 / P70434
  
Possible biological names infered from orthology : Q92985
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141262706
Gene end: 141266481
  
Corresponding Affymetrix probe sets: 10569102 (MoGene1.0st)   1417244_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026571
Ensembl peptide - ENSMUSP00000101644
Ensembl peptide - ENSMUSP00000121026
Ensembl peptide - ENSMUSP00000147529
Ensembl peptide - ENSMUSP00000095565
NCBI entrez gene - 54123     See in Manteia.
MGI - MGI:1859212
RefSeq - XM_006536214
RefSeq - NM_001252600
RefSeq - NM_001252601
RefSeq - NM_016850
RefSeq Peptide - NP_001239530
RefSeq Peptide - NP_058546
RefSeq Peptide - NP_001239529
swissprot - F6TQ89
swissprot - D3Z4U9
swissprot - Q542T3
swissprot - Q3TW14
swissprot - A0A1B0GRH7
swissprot - P70434
Ensembl - ENSMUSG00000025498
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf7ENSDARG00000045661Danio rerio
 IRF7ENSGALG00000014297Gallus gallus
 IRF7ENSG00000185507Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663825
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*ENSMUSG0000000318425
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*ENSMUSG0000002977125
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*ENSMUSG0000002135622
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*ENSMUSG0000004151520
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*ENSMUSG0000000232518
Irf1 / P15314 / interferon regulatory factor 1 / P10914*ENSMUSG0000001889912
Irf2 / P23906 / interferon regulatory factor 2 / P14316*ENSMUSG0000003162712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002819 regulation of adaptive immune response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0032481 positive regulation of type I interferon production IGI
 biological_processGO:0032607 interferon-alpha production IMP
 biological_processGO:0032608 interferon-beta production IMP
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway IMP
 biological_processGO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045088 regulation of innate immune response TAS
 biological_processGO:0045351 type I interferon biosynthetic process IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Gpr149tm1.1Zuk/Gpr149+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Irf7m1Btlr/Irf7+
Genetic Background: C57BL/6J-Irf7m1Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Irf7m1Btlr/Irf7m1Btlr
Genetic Background: C57BL/6J-Irf7m1Btlr

Allelic Composition: Irf7m1Btlr/Irf7+
Genetic Background: C57BL/6J-Irf7m1Btlr

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

Allelic Composition: Irf7M2Btlr/Irf7+
Genetic Background: C57BL/6J-Irf7M2Btlr

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / reaction / complex
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / reaction / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000040522 Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*  / reaction / complex
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr