ENSMUSG00000042349


Mus musculus

Features
Gene ID: ENSMUSG00000042349
  
Biological name :Ikbke
  
Synonyms : Ikbke / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q9R0T8
  
Possible biological names infered from orthology : Q14164
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 131254343
Gene end: 131279606
  
Corresponding Affymetrix probe sets: 10357604 (MoGene1.0st)   1417813_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124190
Ensembl peptide - ENSMUSP00000124486
Ensembl peptide - ENSMUSP00000054126
NCBI entrez gene - 56489     See in Manteia.
MGI - MGI:1929612
RefSeq - XM_006529762
RefSeq - XM_011248052
RefSeq - NM_019777
RefSeq Peptide - NP_062751
swissprot - Q9R0T8
swissprot - E9PYL6
swissprot - E0CY50
Ensembl - ENSMUSG00000042349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ikbkeENSDARG00000070606Danio rerio
 IKBKEENSGALG00000013356Gallus gallus
 IKBKEENSG00000263528Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*ENSMUSG0000002011547
Ikbkb / inhibitor of kappaB kinase beta / O14920* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSMUSG0000003153720
Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSMUSG0000002519920
Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*ENSMUSG0000002951220
Ulk2 / Q9QY01 / unc-51 like kinase 2 / Q8IYT8* / unc-51 like autophagy activating kinase 2*ENSMUSG0000000479818
Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*ENSMUSG0000003230814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010884 positive regulation of lipid storage IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0034340 response to type I interferon IDA
 biological_processGO:0035456 response to interferon-beta IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0098586 cellular response to virus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036435 K48-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of immune response proteins
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Tf/Foxo1tm1Tf
Genetic Background: involves: C57BL/6J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Zbtb17tm1Cksn/Zbtb17tm1Cksn,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Zbtb17tm1Cksn/Zbtb17tm1Cksn,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Zbtb17tm1Cksn/Zbtb17tm1Cksn,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Zbtb17tm1Cksn/Zbtb17tm1Cksn,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Zbtb17tm1Cksn/Zbtb17tm1Cksn,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / reaction / complex
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / reaction / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex / reaction
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / reaction / complex
 ENSMUSG00000004535 Q3UKC1 / Tax1bp1 / Tax1-binding / Q86VP1* / Tax1 binding protein 1*  / reaction / complex






 

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