ENSG00000263528


Homo sapiens

Features
Gene ID: ENSG00000263528
  
Biological name :IKBKE
  
Synonyms : IKBKE / inhibitor of nuclear factor kappa B kinase subunit epsilon / Q14164
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 206470476
Gene end: 206496889
  
Corresponding Affymetrix probe sets: 204549_at (Human Genome U133 Plus 2.0 Array)   214398_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464030
Ensembl peptide - ENSP00000474422
Ensembl peptide - ENSP00000474229
Ensembl peptide - ENSP00000473833
Ensembl peptide - ENSP00000462396
NCBI entrez gene - 9641     See in Manteia.
OMIM - 605048
RefSeq - NM_014002
RefSeq - XM_017002868
RefSeq - XM_005273356
RefSeq - NM_001193321
RefSeq - NM_001193322
RefSeq Peptide - NP_001180250
RefSeq Peptide - NP_001180251
RefSeq Peptide - NP_054721
swissprot - A0A075B7C7
swissprot - Q14164
swissprot - A0A075B7D5
swissprot - A0A075B7B4
Ensembl - ENSG00000263528
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ikbkeENSDARG00000070606Danio rerio
 IKBKEENSGALG00000013356Gallus gallus
 IkbkeENSMUSG00000042349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBK1 / Q9UHD2 / TANK binding kinase 1ENSG0000018373549
ULK1 / O75385 / unc-51 like autophagy activating kinase 1ENSG0000017716920
IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit betaENSG0000010436520
CHUK / O15111 / conserved helix-loop-helix ubiquitous kinaseENSG0000021334120
ULK2 / Q8IYT8 / unc-51 like autophagy activating kinase 2ENSG0000008329019
ULK3 / Q6PHR2 / unc-51 like kinase 3ENSG0000014047413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0010884 positive regulation of lipid storage IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0034340 response to type I interferon IEA
 biological_processGO:0035456 response to interferon-beta IMP
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0098586 cellular response to virus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0031966 mitochondrial membrane IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036435 K48-linked polyubiquitin modification-dependent protein binding IMP


Pathways (from Reactome)
Pathway description
SUMOylation of immune response proteins
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction / complex
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / reaction / complex
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / reaction / complex
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / reaction / complex
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction / complex
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / reaction / complex
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / reaction / complex
 ENSG00000052723 SIKE1 / Q9BRV8 / suppressor of IKBKE 1  / complex
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / reaction / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000118503 P21580 / TNFAIP3 / TNF alpha induced protein 3  / complex / reaction
 ENSG00000106052 Q86VP1 / TAX1BP1 / Tax1 binding protein 1  / reaction / complex
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / reaction / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / complex / reaction
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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