ENSG00000170458


Homo sapiens

Features
Gene ID: ENSG00000170458
  
Biological name :CD14
  
Synonyms : CD14 / CD14 molecule / P08571
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.3
Gene start: 140631728
Gene end: 140633701
  
Corresponding Affymetrix probe sets: 201743_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385519
Ensembl peptide - ENSP00000430884
Ensembl peptide - ENSP00000426543
Ensembl peptide - ENSP00000425447
Ensembl peptide - ENSP00000304236
NCBI entrez gene - 929     See in Manteia.
OMIM - 158120
RefSeq - NM_001040021
RefSeq - NM_001174104
RefSeq - NM_001174105
RefSeq - NM_000591
RefSeq Peptide - NP_000582
RefSeq Peptide - NP_001167575
RefSeq Peptide - NP_001167576
RefSeq Peptide - NP_001035110
swissprot - P08571
swissprot - D6RFL4
swissprot - D6RD81
swissprot - E7EVL5
Ensembl - ENSG00000170458
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD14ENSGALG00000039140Gallus gallus
 Cd14ENSMUSG00000051439Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR016337  Monocyte differentiation antigen CD14
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002237 response to molecule of bacterial origin IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006909 phagocytosis TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032481 positive regulation of type I interferon production IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production ISS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0034142 toll-like receptor 4 signaling pathway ISS
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0038123 toll-like receptor TLR1:TLR2 signaling pathway TAS
 biological_processGO:0038124 toll-like receptor TLR6:TLR2 signaling pathway TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0070266 necroptotic process TAS
 biological_processGO:0071219 cellular response to molecule of bacterial origin IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071223 cellular response to lipoteichoic acid IDA
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IDA
 biological_processGO:0071727 cellular response to triacyl bacterial lipopeptide IDA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046696 lipopolysaccharide receptor complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0001847 opsonin receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016019 peptidoglycan receptor activity TAS
 molecular_functionGO:0070891 lipoteichoic acid binding IDA
 molecular_functionGO:0071723 lipopeptide binding IDA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
Transfer of LPS from LBP carrier to CD14
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent TLR4 cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
TICAM1,TRAF6-dependent induction of TAK1 complex
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129465 RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3  / reaction / complex
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / complex / reaction
 ENSG00000129988 LBP / P18428 / lipopolysaccharide binding protein  / reaction
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / reaction / complex
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / reaction / complex
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / complex / reaction
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / complex / reaction
 ENSG00000160255 ITGB2 / P05107 / integrin subunit beta 2  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000174125 TLR1 / Q15399 / toll like receptor 1  / complex / reaction
 ENSG00000169896 ITGAM / P11215 / integrin subunit alpha M  / reaction / complex
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / reaction / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000004139 SARM1 / Q6SZW1 / sterile alpha and TIR motif containing 1  / reaction / complex
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / reaction / complex
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex
 ENSG00000137462 TLR2 / O60603 / toll like receptor 2  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / reaction / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction / complex
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000174130 TLR6 / Q9Y2C9 / toll like receptor 6  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction / complex
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / reaction / complex
 ENSG00000135218 CD36 / P16671 / CD36 molecule  / reaction / complex
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction / complex






 

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