ENSG00000129465


Homo sapiens

Features
Gene ID: ENSG00000129465
  
Biological name :RIPK3
  
Synonyms : Q9Y572 / receptor interacting serine/threonine kinase 3 / RIPK3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24336021
Gene end: 24340045
  
Corresponding Affymetrix probe sets: 228139_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451840
Ensembl peptide - ENSP00000452328
Ensembl peptide - ENSP00000216274
NCBI entrez gene - 11035     See in Manteia.
OMIM - 605817
RefSeq - NM_006871
RefSeq Peptide - NP_006862
swissprot - H0YJN5
swissprot - Q9Y572
Ensembl - ENSG00000129465
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk3ENSDARG00000090965Danio rerio
 Ripk3ENSMUSG00000022221Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANKK1 / Q8NFD2 / ankyrin repeat and kinase domain containing 1ENSG0000017020924
RIPK4 / P57078 / receptor interacting serine/threonine kinase 4ENSG0000018342123
RIPK2 / O43353 / receptor interacting serine/threonine kinase 2ENSG0000010431222
RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1ENSG0000013727522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025735  RHIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001914 regulation of T cell mediated cytotoxicity ISS
 biological_processGO:0002819 regulation of adaptive immune response ISS
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0010922 positive regulation of phosphatase activity IMP
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032147 activation of protein kinase activity IMP
 biological_processGO:0032649 regulation of interferon-gamma production ISS
 biological_processGO:0033077 T cell differentiation in thymus ISS
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0043029 T cell homeostasis ISS
 biological_processGO:0046006 regulation of activated T cell proliferation ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048535 lymph node development ISS
 biological_processGO:0048536 spleen development ISS
 biological_processGO:0048538 thymus development ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051291 protein heterooligomerization IMP
 biological_processGO:0051351 positive regulation of ligase activity IEA
 biological_processGO:0051353 positive regulation of oxidoreductase activity IEA
 biological_processGO:0060545 positive regulation of necroptotic process IMP
 biological_processGO:0070235 regulation of activation-induced cell death of T cells ISS
 biological_processGO:0070266 necroptotic process IMP
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:1990000 amyloid fibril formation IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000452 regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IMP


Pathways (from Reactome)
Pathway description
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
RIPK1-mediated regulated necrosis
TLR3-mediated TICAM1-dependent programmed cell death
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129465 RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3  / complex / - / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction / complex
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / complex / reaction
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / reaction / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / - / reaction / complex
 ENSG00000124256 ZBP1 / Q9H171 / Z-DNA binding protein 1  / complex / reaction
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction
 ENSG00000168404 MLKL / Q8NB16 / mixed lineage kinase domain like pseudokinase  / complex / reaction






 

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