ENSMUSG00000022221


Mus musculus

Features
Gene ID: ENSMUSG00000022221
  
Biological name :Ripk3
  
Synonyms : Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Ripk3
  
Possible biological names infered from orthology : Q9Y572
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 55784995
Gene end: 55788865
  
Corresponding Affymetrix probe sets: 10420198 (MoGene1.0st)   1448449_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154235
Ensembl peptide - ENSMUSP00000022830
Ensembl peptide - ENSMUSP00000126306
Ensembl peptide - ENSMUSP00000137278
Ensembl peptide - ENSMUSP00000153911
NCBI entrez gene - 56532     See in Manteia.
MGI - MGI:2154952
RefSeq - NM_001164107
RefSeq - NM_001164108
RefSeq - NM_019955
RefSeq Peptide - NP_064339
RefSeq Peptide - NP_001157579
RefSeq Peptide - NP_001157580
swissprot - Q9QZL0
swissprot - E9PZP3
Ensembl - ENSMUSG00000022221
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk3ENSDARG00000090965Danio rerio
 RIPK3ENSG00000129465Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ripk4 / Q9ERK0 / Receptor-interacting serine/threonine-protein kinase 4 / P57078* / receptor interacting serine/threonine kinase 4*ENSMUSG0000000525125
Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*ENSMUSG0000002140824
Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*ENSMUSG0000004113523
Ankk1 / Q8BZ25 / Ankyrin repeat and protein kinase domain-containing protein 1 / Q8NFD2* / ankyrin repeat and kinase domain containing 1*ENSMUSG0000003225722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025735  RHIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001914 regulation of T cell mediated cytotoxicity IGI
 biological_processGO:0002819 regulation of adaptive immune response IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0010922 positive regulation of phosphatase activity IEA
 biological_processGO:0010940 positive regulation of necrotic cell death IMP
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032649 regulation of interferon-gamma production IGI
 biological_processGO:0033077 T cell differentiation in thymus IGI
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0043029 T cell homeostasis IGI
 biological_processGO:0046006 regulation of activated T cell proliferation IGI
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048535 lymph node development IGI
 biological_processGO:0048536 spleen development IGI
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051351 positive regulation of ligase activity IDA
 biological_processGO:0051353 positive regulation of oxidoreductase activity IDA
 biological_processGO:0060545 positive regulation of necroptotic process IMP
 biological_processGO:0070235 regulation of activation-induced cell death of T cells IGI
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000452 regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation IGI
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
TRIF-mediated programmed cell death
TRP channels
RIPK1-mediated regulated necrosis
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Casp8tm1.1Vmd/Casp8tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Casp8tm1.1Vmd/Casp8tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Fsttm1Zuk/Fsttm1Zuk,Wfikkn1tm1.1Sjl/Wfikkn1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm16Sia/Gt(ROSA)26Sortm16Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002220 large lymphoid organs "increased size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Fsttm1Zuk/Fsttm1Zuk,Wfikkn1tm1.1Sjl/Wfikkn1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0004155 resistance to induced pancreatitis "reduced or absent inflammatory response in the pancreatic tissue after experimental manipulation" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Casp8tm1.1Vmd/Casp8tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009631 enlarged axillary lymph nodes "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm16Sia/Gt(ROSA)26Sortm16Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk1tm1Led/Ripk1tm1Led
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Zbp1tm1Aki/Zbp1tm1Aki
Genetic Background: involves: C57BL/6N

Allelic Composition: Mlkltm1.2Wsa/Mlkltm1.2Wsa,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Cyldtm1Scs/Cyldtm1Scs,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Tnfrsf25tm1Lex/Tnfrsf25tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Cflartm1Ywh/Cflartm1Ywh,Gt(ROSA)26Sortm16(cre)Arte/Gt(ROSA)26Sor+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac

 MP:0014080 fused small intestinal villi "partial or complete fusion of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0014083 blunted small intestinal villi "abnormal flattening of the surface of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually due to intestinal damage or injury" [MGI:Anna, PMID:16679353]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / reaction / complex
 ENSMUSG00000012519 Mlkl / Q9D2Y4 / Mixed lineage kinase domain-like protein / Q8NB16* / mixed lineage kinase domain like pseudokinase*  / reaction / complex
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / reaction / complex / -
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000022221 Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*  / reaction / complex / -






 

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