ENSMUSG00000025779


Mus musculus

Features
Gene ID: ENSMUSG00000025779
  
Biological name :Ly96
  
Synonyms : Ly96 / lymphocyte antigen 96 / Q9JHF9
  
Possible biological names infered from orthology : Q9Y6Y9
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A3
Gene start: 16688051
Gene end: 16709611
  
Corresponding Affymetrix probe sets: 10344966 (MoGene1.0st)   1449874_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026881
Ensembl peptide - ENSMUSP00000140411
NCBI entrez gene - 17087     See in Manteia.
MGI - MGI:1341909
RefSeq - NM_001159711
RefSeq - NM_016923
RefSeq Peptide - NP_001153183
RefSeq Peptide - NP_058619
swissprot - Q9JHF9
swissprot - Q14AM4
swissprot - A0A087WQZ9
Ensembl - ENSMUSG00000025779
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LY96ENSGALG00000032701Gallus gallus
 LY96ENSG00000154589Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003172  MD-2-related lipid-recognition domain
 IPR014756  Immunoglobulin E-set


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032497 detection of lipopolysaccharide ISS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0046696 lipopolysaccharide receptor complex IEA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Regulation of TLR by endogenous ligand
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+
Genetic Background: involves: 129S/SvEv * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000022221 Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*  / complex / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000056071 P31725 / S100a9 / S100 calcium binding protein A9 (calgranulin B) / P06702* / S100 calcium binding protein A9*  / complex / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / reaction / complex
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / reaction / complex
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000021789 Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*  / reaction / complex
 ENSMUSG00000066551 Hmgb1 / P63158 / High mobility group protein B1 / P09429* / high mobility group box 1*  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSMUSG00000056054 P27005 / S100a8 / S100 calcium binding protein A8 (calgranulin A) / P05109* / S100 calcium binding protein A8*  / reaction / complex
 ENSMUSG00000050132 Sarm1 / Q6PDS3 / Sterile alpha and TIR motif-containing protein 1 / Q6SZW1* / sterile alpha and TIR motif containing 1*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSMUSG00000021795 Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*  / complex / reaction
 ENSMUSG00000044080 S100a1 / S100 calcium binding protein A1 / P23297*  / complex / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / reaction / complex
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction / complex
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / reaction / complex
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / reaction / complex
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction






 

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