ENSMUSG00000066551


Mus musculus

Features
Gene ID: ENSMUSG00000066551
  
Biological name :Hmgb1
  
Synonyms : High mobility group protein B1 / Hmgb1 / P63158
  
Possible biological names infered from orthology : high mobility group box 1 / P09429
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G3
Gene start: 149046702
Gene end: 149184489
  
Corresponding Affymetrix probe sets: 10385426 (MoGene1.0st)   10535894 (MoGene1.0st)   1416176_at (Mouse Genome 430 2.0 Array)   1425048_a_at (Mouse Genome 430 2.0 Array)   1435324_x_at (Mouse Genome 430 2.0 Array)   1439463_x_at (Mouse Genome 430 2.0 Array)   1448235_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106131
Ensembl peptide - ENSMUSP00000106132
Ensembl peptide - ENSMUSP00000144412
Ensembl peptide - ENSMUSP00000144129
Ensembl peptide - ENSMUSP00000118733
Ensembl peptide - ENSMUSP00000114515
Ensembl peptide - ENSMUSP00000082682
NCBI entrez gene - 100862258     See in Manteia.
NCBI entrez gene - 15289     See in Manteia.
MGI - MGI:96113
RefSeq - NM_010439
RefSeq - NM_001313894
RefSeq Peptide - NP_001300823
RefSeq Peptide - NP_034569
swissprot - D3YZ18
swissprot - Q58EV5
swissprot - D3YVC6
swissprot - A0A0J9YUZ4
swissprot - A0A0J9YUD8
swissprot - P63158
Ensembl - ENSMUSG00000066551
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgb1aENSDARG00000099175Danio rerio
 hmgb1bENSDARG00000030479Danio rerio
 HMGB1ENSGALG00000042875Gallus gallus
 HMGB1ENSG00000189403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmgb2 / P30681 / High mobility group protein B2 / P26583* / high mobility group box 2*ENSMUSG0000005471779
Hmgb3 / O54879 / High mobility group protein B3 ENSMUSG0000001521770
Hmgb4 / Q6P8W9 / High mobility group protein B4 / Q8WW32* / high mobility group box 4*ENSMUSG0000004868634


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017967  HMG box A DNA-binding domain, conserved site
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001654 eye development IMP
 biological_processGO:0001773 myeloid dendritic cell activation IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001935 endothelial cell proliferation IDA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation ISO
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002270 plasmacytoid dendritic cell activation IMP
 biological_processGO:0002281 macrophage activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0002643 regulation of tolerance induction IMP
 biological_processGO:0002840 regulation of T cell mediated immune response to tumor cell IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IMP
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0031497 chromatin assembly IDA
 biological_processGO:0032072 regulation of restriction endodeoxyribonuclease activity IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032392 DNA geometric change ISO
 biological_processGO:0032425 positive regulation of mismatch repair IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IMP
 biological_processGO:0032728 positive regulation of interferon-beta production IMP
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0033151 V(D)J recombination IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IDA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IDA
 biological_processGO:0034165 positive regulation of toll-like receptor 9 signaling pathway ISS
 biological_processGO:0035711 T-helper 1 cell activation IEA
 biological_processGO:0035767 endothelial cell chemotaxis IDA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043277 apoptotic cell clearance ISS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045063 T-helper 1 cell differentiation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IDA
 biological_processGO:0045819 positive regulation of glycogen catabolic process IMP
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050716 positive regulation of interleukin-1 secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IMP
 biological_processGO:0050930 induction of positive chemotaxis ISO
 biological_processGO:0051106 positive regulation of DNA ligation ISS
 biological_processGO:0051384 response to glucocorticoid IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 biological_processGO:0090303 positive regulation of wound healing IDA
 biological_processGO:0097350 neutrophil clearance ISS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IDA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:1990774 tumor necrosis factor secretion IEA
 biological_processGO:2000426 negative regulation of apoptotic cell clearance IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 biological_processGO:2000819 regulation of nucleotide-excision repair IMP
 biological_processGO:2001200 positive regulation of dendritic cell differentiation IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0000400 four-way junction DNA binding ISS
 molecular_functionGO:0000401 open form four-way junction DNA binding ISO
 molecular_functionGO:0000402 crossed form four-way junction DNA binding ISO
 molecular_functionGO:0000405 bubble DNA binding ISS
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003681 bent DNA binding ISO
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008301 DNA binding, bending ISS
 molecular_functionGO:0010858 calcium-dependent protein kinase regulator activity IDA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019958 C-X-C chemokine binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IDA
 molecular_functionGO:0070182 DNA polymerase binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0097100 supercoiled DNA binding ISS


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
Activation of DNA fragmentation factor
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002715 reduced glycogen catabolism rate "decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004761 susceptibility to induced pancreatitis "more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008684 increased interleukin-18 secretion "increase in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009148 pancreas necrosis "pathological cell death in the pancreas, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pkd1tm1Jzh/Pkd1tm1Jzh
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011971 increased circulating lactate dehydrogenase level "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex






 

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