ENSGALG00000042875


Gallus gallus

Features
Gene ID: ENSGALG00000042875
  
Biological name :HMGB1
  
Synonyms : High mobility group protein B1 / HMGB1 / Q9YH06
  
Possible biological names infered from orthology : high mobility group box 1 / P09429 / P63158
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 175162513
Gene end: 175170894
  
Corresponding Affymetrix probe sets: Gga.4638.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000061955
Ensembl peptide - ENSGALP00000044781
Ensembl peptide - ENSGALP00000047606
NCBI entrez gene - 395724     See in Manteia.
RefSeq - XM_015277670
RefSeq - NM_204902
RefSeq - XM_015277667
RefSeq Peptide - NP_990233
swissprot - Q9YH06
swissprot - A0A1L1RT25
Ensembl - ENSGALG00000042875
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgb1aENSDARG00000099175Danio rerio
 hmgb1bENSDARG00000030479Danio rerio
 HMGB1ENSG00000189403Homo sapiens
 Hmgb1ENSMUSG00000066551Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HMGB2 / high mobility group protein B2 / P26583* / P30681* / high mobility group box 2*ENSGALG0000001074578
HMGB3 / P40618 / High mobility group protein B3 / O15347* / O54879* / high mobility group box 3*ENSGALG0000000907168


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017967  HMG box A DNA-binding domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001773 myeloid dendritic cell activation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002270 plasmacytoid dendritic cell activation IEA
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0002643 regulation of tolerance induction IEA
 biological_processGO:0002840 regulation of T cell mediated immune response to tumor cell IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031497 chromatin assembly IEA
 biological_processGO:0032072 regulation of restriction endodeoxyribonuclease activity IEA
 biological_processGO:0032392 DNA geometric change IDA
 biological_processGO:0032425 positive regulation of mismatch repair IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033151 V(D)J recombination IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035711 T-helper 1 cell activation IEA
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045063 T-helper 1 cell differentiation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IEA
 biological_processGO:0045819 positive regulation of glycogen catabolic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050716 positive regulation of interleukin-1 secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair ISS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 biological_processGO:0097350 neutrophil clearance IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:1990774 tumor necrosis factor secretion IEA
 biological_processGO:2000426 negative regulation of apoptotic cell clearance IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 biological_processGO:2000819 regulation of nucleotide-excision repair IEA
 biological_processGO:2001200 positive regulation of dendritic cell differentiation IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000400 four-way junction DNA binding IDA
 molecular_functionGO:0000405 bubble DNA binding IDA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0010858 calcium-dependent protein kinase regulator activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019958 C-X-C chemokine binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0044378 non-sequence-specific DNA binding, bending ISS
 molecular_functionGO:0070182 DNA polymerase binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0097100 supercoiled DNA binding IDA


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor
Regulation of TLR by endogenous ligand
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / reaction / complex






 

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