ENSG00000189403


Homo sapiens

Features
Gene ID: ENSG00000189403
  
Biological name :HMGB1
  
Synonyms : high mobility group box 1 / HMGB1 / P09429
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.3
Gene start: 30456704
Gene end: 30617597
  
Corresponding Affymetrix probe sets: 200679_x_at (Human Genome U133 Plus 2.0 Array)   200680_x_at (Human Genome U133 Plus 2.0 Array)   214938_x_at (Human Genome U133 Plus 2.0 Array)   224731_at (Human Genome U133 Plus 2.0 Array)   224734_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000343040
Ensembl peptide - ENSP00000382412
Ensembl peptide - ENSP00000384678
Ensembl peptide - ENSP00000382417
Ensembl peptide - ENSP00000345347
Ensembl peptide - ENSP00000369904
NCBI entrez gene - 3146     See in Manteia.
OMIM - 163905
RefSeq - NM_001313892
RefSeq - NM_001313893
RefSeq - NM_002128
RefSeq Peptide - NP_002119
RefSeq Peptide - NP_001300821
RefSeq Peptide - NP_001300822
swissprot - Q5T7C4
swissprot - P09429
swissprot - A0A024RDR0
Ensembl - ENSG00000189403
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgb1aENSDARG00000099175Danio rerio
 hmgb1bENSDARG00000030479Danio rerio
 HMGB1ENSGALG00000042875Gallus gallus
 Hmgb1ENSMUSG00000066551Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HMGB2 / P26583 / high mobility group box 2ENSG0000016410480
HMGB3 / O15347 / high mobility group box 3ENSG0000002999371
HMGB4 / Q8WW32 / high mobility group box 4ENSG0000017625634


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017967  HMG box A DNA-binding domain, conserved site
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001773 myeloid dendritic cell activation ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002270 plasmacytoid dendritic cell activation IEA
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002407 dendritic cell chemotaxis ISS
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEP
 biological_processGO:0002643 regulation of tolerance induction IDA
 biological_processGO:0002840 regulation of T cell mediated immune response to tumor cell ISS
 biological_processGO:0006265 DNA topological change ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006309 apoptotic DNA fragmentation TAS
 biological_processGO:0006310 DNA recombination ISS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0031497 chromatin assembly IEA
 biological_processGO:0032072 regulation of restriction endodeoxyribonuclease activity IDA
 biological_processGO:0032392 DNA geometric change ISS
 biological_processGO:0032425 positive regulation of mismatch repair IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033151 V(D)J recombination IDA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0034165 positive regulation of toll-like receptor 9 signaling pathway ISS
 biological_processGO:0035711 T-helper 1 cell activation IDA
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043277 apoptotic cell clearance IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation IDA
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045063 T-helper 1 cell differentiation IMP
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IEA
 biological_processGO:0045819 positive regulation of glycogen catabolic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0050716 positive regulation of interleukin-1 secretion IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair ISS
 biological_processGO:0051106 positive regulation of DNA ligation ISS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 biological_processGO:0090303 positive regulation of wound healing IEA
 biological_processGO:0097350 neutrophil clearance IDA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IMP
 biological_processGO:1990774 tumor necrosis factor secretion IDA
 biological_processGO:2000426 negative regulation of apoptotic cell clearance IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IDA
 biological_processGO:2000819 regulation of nucleotide-excision repair IEA
 biological_processGO:2001200 positive regulation of dendritic cell differentiation IMP
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000400 four-way junction DNA binding ISS
 molecular_functionGO:0000405 bubble DNA binding ISS
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding ISS
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005125 cytokine activity ISS
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008301 DNA binding, bending IMP
 molecular_functionGO:0010858 calcium-dependent protein kinase regulator activity IEA
 molecular_functionGO:0016829 lyase activity IDA
 molecular_functionGO:0019958 C-X-C chemokine binding IDA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0042056 chemoattractant activity ISS
 molecular_functionGO:0050786 RAGE receptor binding ISS
 molecular_functionGO:0070182 DNA polymerase binding IDA
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0097100 supercoiled DNA binding ISS


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / reaction / complex






 

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