ENSG00000164104


Homo sapiens

Features
Gene ID: ENSG00000164104
  
Biological name :HMGB2
  
Synonyms : high mobility group box 2 / HMGB2 / P26583
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q34.1
Gene start: 173331695
Gene end: 173335125
  
Corresponding Affymetrix probe sets: 208808_s_at (Human Genome U133 Plus 2.0 Array)   236091_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423001
Ensembl peptide - ENSP00000296503
Ensembl peptide - ENSP00000393448
Ensembl peptide - ENSP00000404912
NCBI entrez gene - 3148     See in Manteia.
OMIM - 163906
RefSeq - NM_001130688
RefSeq - NM_001130689
RefSeq - NM_002129
RefSeq Peptide - NP_001124160
RefSeq Peptide - NP_001124161
RefSeq Peptide - NP_002120
swissprot - P26583
swissprot - D6R9A6
Ensembl - ENSG00000164104
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgb2aENSDARG00000029722Danio rerio
 HMGB2ENSGALG00000010745Gallus gallus
 Hmgb2ENSMUSG00000054717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HMGB1 / P09429 / high mobility group box 1ENSG0000018940382
HMGB3 / O15347 / high mobility group box 3ENSG0000002999370
HMGB4 / Q8WW32 / high mobility group box 4ENSG0000017625637


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017967  HMG box A DNA-binding domain, conserved site
 IPR031075  High mobility group protein HMGB2
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus ISS
 biological_processGO:0006265 DNA topological change ISS
 biological_processGO:0006309 apoptotic DNA fragmentation TAS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization NAS
 biological_processGO:0006334 nucleosome assembly NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007289 spermatid nucleus differentiation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0032075 positive regulation of nuclease activity IDA
 biological_processGO:0032392 DNA geometric change ISS
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0033151 V(D)J recombination ISS
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0050767 regulation of neurogenesis ISS
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair ISS
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEP
 biological_processGO:0072091 regulation of stem cell proliferation ISS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000400 four-way junction DNA binding ISS
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0008144 drug binding ISS
 molecular_functionGO:0008301 DNA binding, bending IDA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0044378 non-sequence-specific DNA binding, bending ISS
 molecular_functionGO:0050786 RAGE receptor binding IGI
 molecular_functionGO:0097100 supercoiled DNA binding ISS


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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