ENSMUSG00000054717


Mus musculus

Features
Gene ID: ENSMUSG00000054717
  
Biological name :Hmgb2
  
Synonyms : High mobility group protein B2 / Hmgb2 / P30681
  
Possible biological names infered from orthology : high mobility group box 2 / P26583
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B2
Gene start: 57511907
Gene end: 57515999
  
Corresponding Affymetrix probe sets: 10510172 (MoGene1.0st)   10518350 (MoGene1.0st)   10518352 (MoGene1.0st)   10571870 (MoGene1.0st)   1437313_x_at (Mouse Genome 430 2.0 Array)   1438307_at (Mouse Genome 430 2.0 Array)   1452534_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147297
Ensembl peptide - ENSMUSP00000065940
NCBI entrez gene - 97165     See in Manteia.
MGI - MGI:96157
RefSeq - NM_008252
RefSeq - XM_006509524
RefSeq Peptide - NP_032278
swissprot - A0A1B0GQX9
swissprot - P30681
Ensembl - ENSMUSG00000054717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgb2aENSDARG00000029722Danio rerio
 HMGB2ENSGALG00000010745Gallus gallus
 HMGB2ENSG00000164104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmgb1 / P63158 / High mobility group protein B1 / P09429* / high mobility group box 1*ENSMUSG0000006655180
Hmgb3 / O54879 / High mobility group protein B3 ENSMUSG0000001521770
Hmgb4 / Q6P8W9 / High mobility group protein B4 / Q8WW32* / high mobility group box 4*ENSMUSG0000004868635


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017967  HMG box A DNA-binding domain, conserved site
 IPR031075  High mobility group protein HMGB2
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IMP
 biological_processGO:0006265 DNA topological change ISS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007289 spermatid nucleus differentiation IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0032075 positive regulation of nuclease activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032728 positive regulation of interferon-beta production IMP
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048545 response to steroid hormone IMP
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0072091 regulation of stem cell proliferation IMP
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044378 non-sequence-specific DNA binding, bending ISS
 molecular_functionGO:0050786 RAGE receptor binding IEA
 molecular_functionGO:0097100 supercoiled DNA binding ISS


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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