ENSGALG00000010745


Gallus gallus

Features
Gene ID: ENSGALG00000010745
  
Biological name :HMGB2
  
Synonyms : high mobility group protein B2 / HMGB2
  
Possible biological names infered from orthology : high mobility group box 2 / P26583 / P30681
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 43583240
Gene end: 43585370
  
Corresponding Affymetrix probe sets: Gga.4061.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048866
Ensembl peptide - ENSGALP00000017462
NCBI entrez gene - 396482     See in Manteia.
RefSeq - NM_205486
RefSeq Peptide - NP_990817
swissprot - F1NPU8
swissprot - A0A1D5P821
Ensembl - ENSGALG00000010745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgb2aENSDARG00000029722Danio rerio
 HMGB2ENSG00000164104Homo sapiens
 Hmgb2ENSMUSG00000054717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HMGB1 / Q9YH06 / High mobility group protein B1 / P09429* / P63158* / high mobility group box 1*ENSGALG0000004287581
HMGB3 / P40618 / High mobility group protein B3 / O15347* / O54879* / high mobility group box 3*ENSGALG0000000907169


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017967  HMG box A DNA-binding domain, conserved site
 IPR031075  High mobility group protein HMGB2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007289 spermatid nucleus differentiation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0032075 positive regulation of nuclease activity IEA
 biological_processGO:0032392 DNA geometric change IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0072091 regulation of stem cell proliferation IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000400 four-way junction DNA binding IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008144 drug binding ISS
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0050786 RAGE receptor binding IEA


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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