3146


Homo sapiens (NCBI)

Features
Gene ID: 3146
  
Biological name :
  
Synonyms : high mobility group box 1 / HMG-1|HMG1|HMG3|SBP-1 / HMGB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 200679_x_at (Human Genome U133 Plus 2.0 Array)   200680_x_at (Human Genome U133 Plus 2.0 Array)   214938_x_at (Human Genome U133 Plus 2.0 Array)   224731_at (Human Genome U133 Plus 2.0 Array)   224734_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - XP_024305112.1
RefSeq - 1370463795
RefSeq - 1370463797
RefSeq - 1370463799
RefSeq - 1370463801
RefSeq - 1393169616
RefSeq - 4504425
RefSeq - 926459555
RefSeq - 926459557
RefSeq - NC_000013.11
RefSeq - NP_001300821.1
RefSeq - NP_001300822.1
RefSeq - NP_001350590.1
RefSeq - NP_002119.1
RefSeq - XP_024305108.1
RefSeq - XP_024305109.1
RefSeq - XP_024305110.1
RefSeq - XP_024305111.1
RefSeq - 1370463793
RefSeq - NM_001313892.1
RefSeq - NM_001313893.1
RefSeq - NM_001363661.1
RefSeq - NM_002128.6
RefSeq - XM_024449341.1
RefSeq - XM_024449342.1
RefSeq - XM_024449343.1
RefSeq - XM_024449344.1
RefSeq - XM_024449340.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000189403 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001773 myeloid dendritic cell activation ISS
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002270 plasmacytoid dendritic cell activation IEA
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0002407 dendritic cell chemotaxis ISS
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEP
 biological_processGO:0002643 regulation of tolerance induction IDA
 biological_processGO:0002840 regulation of T cell mediated immune response to tumor cell ISS
 biological_processGO:0006265 DNA topological change ISS
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006309 apoptotic DNA fragmentation TAS
 biological_processGO:0006310 DNA recombination ISS
 biological_processGO:0006338 chromatin remodeling IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0031497 chromatin assembly IEA
 biological_processGO:0032072 regulation of restriction endodeoxyribonuclease activity IDA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032392 DNA geometric change ISS
 biological_processGO:0032425 positive regulation of mismatch repair IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033151 V(D)J recombination IDA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0034165 positive regulation of toll-like receptor 9 signaling pathway ISS
 biological_processGO:0035711 T-helper 1 cell activation IDA
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043277 apoptotic cell clearance IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation IDA
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045063 T-helper 1 cell differentiation IMP
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IEA
 biological_processGO:0045819 positive regulation of glycogen catabolic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0050716 positive regulation of interleukin-1 secretion IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair ISS
 biological_processGO:0051106 positive regulation of DNA ligation ISS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 biological_processGO:0090303 positive regulation of wound healing IEA
 biological_processGO:0097350 neutrophil clearance IDA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IMP
 biological_processGO:1990774 tumor necrosis factor secretion IDA
 biological_processGO:2000426 negative regulation of apoptotic cell clearance IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IDA
 biological_processGO:2000819 regulation of nucleotide-excision repair IEA
 biological_processGO:2001200 positive regulation of dendritic cell differentiation IMP
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000400 four-way junction DNA binding ISS
 molecular_functionGO:0000405 bubble DNA binding ISS
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003684 damaged DNA binding ISS
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005125 cytokine activity ISS
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008301 DNA binding, bending ISS
 molecular_functionGO:0010858 calcium-dependent protein kinase regulator activity IEA
 molecular_functionGO:0016829 lyase activity IDA
 molecular_functionGO:0019958 C-X-C chemokine binding IDA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0042056 chemoattractant activity ISS
 molecular_functionGO:0050786 RAGE receptor binding ISS
 molecular_functionGO:0070182 DNA polymerase binding IDA
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0097100 supercoiled DNA binding ISS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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