ENSMUSG00000021408


Mus musculus

Features
Gene ID: ENSMUSG00000021408
  
Biological name :Ripk1
  
Synonyms : Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Ripk1
  
Possible biological names infered from orthology : Q13546 / receptor interacting serine/threonine kinase 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.3
Gene start: 34002363
Gene end: 34037147
  
Corresponding Affymetrix probe sets: 10404506 (MoGene1.0st)   1419508_at (Mouse Genome 430 2.0 Array)   1439273_at (Mouse Genome 430 2.0 Array)   1449485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021844
Ensembl peptide - ENSMUSP00000128511
Ensembl peptide - ENSMUSP00000129831
NCBI entrez gene - 19766     See in Manteia.
MGI - MGI:108212
RefSeq - XM_011244295
RefSeq - NM_009068
RefSeq - XM_006516607
RefSeq - XM_006516609
RefSeq Peptide - NP_033094
swissprot - F7D1J2
swissprot - Q60855
Ensembl - ENSMUSG00000021408
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk1lENSDARG00000006677Danio rerio
 RIPK1ENSGALG00000012827Gallus gallus
 RIPK1ENSG00000137275Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ripk4 / Q9ERK0 / Receptor-interacting serine/threonine-protein kinase 4 / P57078* / receptor interacting serine/threonine kinase 4*ENSMUSG0000000525120
Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*ENSMUSG0000002222118
Ankk1 / Q8BZ25 / Ankyrin repeat and protein kinase domain-containing protein 1 / Q8NFD2* / ankyrin repeat and kinase domain containing 1*ENSMUSG0000003225718
Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*ENSMUSG0000004113517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR025735  RHIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007257 activation of JUN kinase activity IBA
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0042327 positive regulation of phosphorylation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060545 positive regulation of necroptotic process IEA
 biological_processGO:0070231 T cell apoptotic process IMP
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:0070926 regulation of ATP:ADP antiporter activity IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097343 ripoptosome assembly IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:1901026 ripoptosome assembly involved in necroptotic process IGI
 biological_processGO:1905206 positive regulation of hydrogen peroxide-induced cell death IEA
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097342 ripoptosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0070513 death domain binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
TRP channels
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Ovarian tumor domain proteases
Dimerization of procaspase-8
TNF signaling
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0005535 abnormal body temperature "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk1tm1Led/Ripk1tm1Led
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk1tm1Led/Ripk1+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
Show

Allelic Composition: Ripk1tm1.1Vmd/Ripk1tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
Show

Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / complex
 ENSMUSG00000022221 Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*  / reaction / complex / -
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction / complex
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / complex / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000053483 Usp21 / ubiquitin specific peptidase 21 / Q9UK80*  / complex
 ENSMUSG00000031887 Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000036712 Cyld / Q80TQ2 / Ubiquitin carboxyl-terminal hydrolase CYLD / Q9NQC7* / CYLD lysine 63 deubiquitinase*  / complex
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / reaction / complex
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / reaction / complex
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / - / complex / reaction
 ENSMUSG00000012519 Mlkl / Q9D2Y4 / Mixed lineage kinase domain-like protein / Q8NB16* / mixed lineage kinase domain like pseudokinase*  / reaction / complex
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / reaction / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / reaction / complex






 

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