ENSMUSG00000004221


Mus musculus

Features
Gene ID: ENSMUSG00000004221
  
Biological name :Ikbkg
  
Synonyms : Ikbkg / NF-kappa-B essential modulator / O88522
  
Possible biological names infered from orthology : inhibitor of nuclear factor kappa B kinase subunit gamma / Q9Y6K9
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 74393290
Gene end: 74453854
  
Corresponding Affymetrix probe sets: 10600453 (MoGene1.0st)   1421208_at (Mouse Genome 430 2.0 Array)   1421209_s_at (Mouse Genome 430 2.0 Array)   1435646_at (Mouse Genome 430 2.0 Array)   1435647_at (Mouse Genome 430 2.0 Array)   1450161_at (Mouse Genome 430 2.0 Array)   1454690_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115706
Ensembl peptide - ENSMUSP00000115829
Ensembl peptide - ENSMUSP00000136573
Ensembl peptide - ENSMUSP00000126770
Ensembl peptide - ENSMUSP00000120080
Ensembl peptide - ENSMUSP00000118884
Ensembl peptide - ENSMUSP00000116875
Ensembl peptide - ENSMUSP00000116615
Ensembl peptide - ENSMUSP00000116230
Ensembl peptide - ENSMUSP00000004330
Ensembl peptide - ENSMUSP00000064017
Ensembl peptide - ENSMUSP00000109762
Ensembl peptide - ENSMUSP00000109763
Ensembl peptide - ENSMUSP00000109764
Ensembl peptide - ENSMUSP00000109765
Ensembl peptide - ENSMUSP00000109768
NCBI entrez gene - 16151     See in Manteia.
MGI - MGI:1338074
RefSeq - XM_011247527
RefSeq - XM_006527847
RefSeq - XM_006527853
RefSeq - XM_006527852
RefSeq - XM_006527851
RefSeq - XM_006527850
RefSeq - XM_006527849
RefSeq - XM_006527848
RefSeq - NM_001136067
RefSeq - NM_001161421
RefSeq - NM_001161422
RefSeq - NM_001161423
RefSeq - NM_001161424
RefSeq - NM_010547
RefSeq - NM_178590
RefSeq Peptide - NP_001154893
RefSeq Peptide - NP_001129539
RefSeq Peptide - NP_001154894
RefSeq Peptide - NP_001154895
RefSeq Peptide - NP_001154896
RefSeq Peptide - NP_034677
RefSeq Peptide - NP_848705
swissprot - O88522
swissprot - Q7TSS3
swissprot - Q8VC91
swissprot - E9Q2Y3
swissprot - A3KG37
swissprot - A3KG38
swissprot - A3KG39
swissprot - A3KG40
swissprot - A3KG41
swissprot - A3KG44
swissprot - D3YYY3
Ensembl - ENSMUSG00000004221
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ikbkgENSDARG00000017037Danio rerio
 IKBKGENSG00000269335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Optn / Q8K3K8 / Mus musculus optineurin (Optn), transcript variant 1, mRNA. / Q96CV9* / optineurin*ENSMUSG0000002667229


Protein motifs (from Interpro)
Interpro ID Name
 IPR021063  NF-kappa-B essential modulator NEMO, N-terminal
 IPR032419  NF-kappa-B essential modulator NEMO, CC2-LZ domain
 IPR034735  NEMO, Zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IDA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0043276 anoikis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051650 establishment of vesicle localization ISO
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000151 ubiquitin ligase complex ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0008385 IkappaB kinase complex ISO
 cellular_componentGO:0072686 mitotic spindle ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:1990450 linear polyubiquitin binding ISO


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0000424 retarded hair growth "slow growth of the hair, appears at normal time" [J:5476]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Ikbkgtm1.1Mpa/Y,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Cyldtm1.1Mpa Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Ikbkgtm1.1Mpa/Y,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: Ikbkgtm1.1Dwat/Ikbkg+
Genetic Background: B6.Cg-Ikbkgtm1.1Dwat

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cd4tm1Yzo/Cd4tm1Yzo,Tg(Cd8a-cre,GFP)1Yzo/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dbitm1Smdp/Dbitm1Smdp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0002658 abnormal liver regeneration "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Ikbkgtm1.1Mpa/Y,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Cyldtm1.1Mpa Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Ikbkgtm1.1Mpa/Y,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: Ikbkgtm1Mpa/Ikbkg+
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkgtm1.1Dwat/Ikbkg+
Genetic Background: B6.Cg-Ikbkgtm1.1Dwat

 MP:0003454 erythroderma "exfoliation and widespread, intense reddening of the skin due to inflammatory skin disease" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95549]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ikbkgtm1Mak/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1Mpa/Ikbkg+
Genetic Background: involves: C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd4tm1Yzo/Cd4tm1Yzo,Tg(Cd8a-cre,GFP)1Yzo/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Ikbkgtm1.1Dwat/Ikbkg+
Genetic Background: B6.Cg-Ikbkgtm1.1Dwat

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005083 abnormal biliary tract morphology "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd4tm1Yzo/Cd4tm1Yzo,Tg(Cd8a-cre,GFP)1Yzo/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1.1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008253 absent megakaryocytes "absence of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ikbkgtm1Mak/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009385 abnormal dermal pigmentation "anomaly in coloration of the dermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1Mpa/Ikbkg+
Genetic Background: involves: C57BL/6

 MP:0009387 abnormal epidermal pigmentation "anomaly in coloration of the epidermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1Mpa/Ikbkg+
Genetic Background: involves: C57BL/6

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ikbkgtm1Mpa/Ikbkg+
Genetic Background: involves: C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Ikbkgtm1.1Chtr/Y,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0011009 increased circulating glutamate dehydrogenase level "increased concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ikbkgtm1Mpa/Ikbkg+
Genetic Background: involves: C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: E2f1tm1Meg/E2f1tm1Meg
Genetic Background: NOD.Cg-E2f1tm1Meg

Allelic Composition: Ikbkgtm1Mak/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ikbkgtm1.1Dwat/Ikbkg+
Genetic Background: B6.Cg-Ikbkgtm1.1Dwat

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0011971 increased circulating lactate dehydrogenase level "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]
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Allelic Composition: Ikbkgtm1.1Dwat/Y,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Ikbkgtm1Mpa/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Ikbkgtm1Mak/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / reaction / complex
 ENSMUSG00000022552 Q91WA6 / Sharpin / Q9H0F6* / SHANK associated RH domain interactor*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000020275 Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*  / reaction
 ENSMUSG00000047098 Rnf31 / Q924T7 / E3 ubiquitin-protein ligase RNF31 / Q96EP0* / AL136295.5* / ring finger protein 31*  / complex / reaction
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / reaction
 ENSMUSG00000020372 Rack1 / P68040 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed / P63244* / receptor for activated C kinase 1*  / complex / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000027466 Rbck1 / Q9WUB0 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / RANBP2-type and C3HC4-type zinc finger containing 1*  / reaction / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / reaction / complex
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / complex / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex / reaction
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / reaction / complex
 ENSMUSG00000036712 Cyld / Q80TQ2 / Ubiquitin carboxyl-terminal hydrolase CYLD / Q9NQC7* / CYLD lysine 63 deubiquitinase*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / reaction






 

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