ENSMUSG00000047098


Mus musculus

Features
Gene ID: ENSMUSG00000047098
  
Biological name :Rnf31
  
Synonyms : E3 ubiquitin-protein ligase RNF31 / Q924T7 / Rnf31
  
Possible biological names infered from orthology : AL136295.5 / Q96EP0 / ring finger protein 31
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 55591708
Gene end: 55603693
  
Corresponding Affymetrix probe sets: 10415293 (MoGene1.0st)   1455051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019443
Ensembl peptide - ENSMUSP00000118215
Ensembl peptide - ENSMUSP00000154756
NCBI entrez gene - 268749     See in Manteia.
MGI - MGI:1934704
RefSeq - NM_194346
RefSeq - XM_006519062
RefSeq Peptide - NP_919327
swissprot - F6XVP7
swissprot - Q924T7
Ensembl - ENSMUSG00000047098
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO834800.1ENSDARG00000090770Danio rerio
 FO834800.2ENSDARG00000113057Danio rerio
 AL136295.5ENSG00000259529Homo sapiens
 RNF31ENSG00000092098Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR002867  IBR domain
 IPR015940  Ubiquitin-associated domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018997  PUB domain
 IPR026254  E3 ubiquitin-protein ligase RNF31
 IPR032065  E3 ubiquitin-protein ligase RNF31, UBA-like domain
 IPR036339  PUB-like domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0023035 CD40 signaling pathway IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0050852 T cell receptor signaling pathway ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0060546 negative regulation of necroptotic process IGI
 biological_processGO:0097039 protein linear polyubiquitination ISO
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0035631 CD40 receptor complex IDA
 cellular_componentGO:0071797 LUBAC complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004940 abnormal B-1 B cell morphology "any structural anomaly in the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ndfip1tm1.1Pmo/Ndfip1tm1.1Pmo,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000022552 Q91WA6 / Sharpin / Q9H0F6* / SHANK associated RH domain interactor*  / complex
 ENSMUSG00000027466 Rbck1 / Q9WUB0 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / RANBP2-type and C3HC4-type zinc finger containing 1*  / complex
 ENSMUSG00000046034 Otulin / Q3UCV8 / Ubiquitin thioesterase otulin / Q96BN8* / OTU deubiquitinase with linear linkage specificity*  / complex / reaction






 

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