ENSMUSG00000022552


Mus musculus

Features
Gene ID: ENSMUSG00000022552
  
Biological name :Sharpin
  
Synonyms : Q91WA6 / Sharpin
  
Possible biological names infered from orthology : Q9H0F6 / SHANK associated RH domain interactor
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76347040
Gene end: 76351111
  
Corresponding Affymetrix probe sets: 10429885 (MoGene1.0st)   1424165_a_at (Mouse Genome 430 2.0 Array)   1451267_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023211
Ensembl peptide - ENSMUSP00000124755
Ensembl peptide - ENSMUSP00000125382
Ensembl peptide - ENSMUSP00000155231
NCBI entrez gene - 106025     See in Manteia.
MGI - MGI:1913331
RefSeq - XM_011245398
RefSeq - NM_025340
RefSeq - XM_006520263
RefSeq Peptide - NP_079616
swissprot - Q91WA6
swissprot - F6UHH8
swissprot - E0CZH2
Ensembl - ENSMUSG00000022552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A9JTG5ENSDARG00000059871Danio rerio
 sharpinENSDARG00000076995Danio rerio
 Q9H0F6ENSG00000179526Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbck1 / Q9WUB0 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / RANBP2-type and C3HC4-type zinc finger containing 1*ENSMUSG0000002746622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR026168  SHARPIN
 IPR029071  Ubiquitin-like domain superfamily
 IPR031912  Sharpin, PH domain
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0030262 apoptotic nuclear changes IMP
 biological_processGO:0031424 keratinization IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0097039 protein linear polyubiquitination IEA
 biological_processGO:2000348 regulation of CD40 signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0071797 LUBAC complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000376 folliculitis "inflammatory reaction in hair follicles " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * CAST/EiJ

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000765 abnormal tongue squamous epithelium morphology "malformation of the scaly epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0000997 abnormal joint capsule morphology "anomalous structure of the sac that encloses the articulating ends of bones participating in a synovial joint " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * CAST/EiJ

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002220 large lymphoid organs "increased size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0003278 esophageal inflammation "local accumulation of fluid, plasma proteins and leukocytes in the esophagus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0003865 lymph node inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0006162 thick eyelids "increased width of the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0009715 thick epidermis stratum basale "increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lattm1Les/Lattm1Les,Tg(CD2-LAT2)1Wz/0
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction / complex
 ENSMUSG00000027466 Rbck1 / Q9WUB0 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / RANBP2-type and C3HC4-type zinc finger containing 1*  / complex
 ENSMUSG00000047098 Rnf31 / Q924T7 / E3 ubiquitin-protein ligase RNF31 / Q96EP0* / AL136295.5* / ring finger protein 31*  / complex
 ENSMUSG00000046034 Otulin / Q3UCV8 / Ubiquitin thioesterase otulin / Q96BN8* / OTU deubiquitinase with linear linkage specificity*  / complex / reaction






 

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