ENSG00000179526


Homo sapiens

Features
Gene ID: ENSG00000179526
  
Biological name :SHARPIN
  
Synonyms : Q9H0F6 / SHANK associated RH domain interactor / SHARPIN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 144098633
Gene end: 144108124
  
Corresponding Affymetrix probe sets: 220973_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000352551
Ensembl peptide - ENSP00000381698
Ensembl peptide - ENSP00000432355
NCBI entrez gene - 81858     See in Manteia.
OMIM - 611885
RefSeq - XM_017013888
RefSeq - NM_030974
RefSeq - XM_017013887
RefSeq Peptide - NP_112236
swissprot - Q9H0F6
swissprot - H0YCU2
Ensembl - ENSG00000179526
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A9JTG5ENSDARG00000059871Danio rerio
 sharpinENSDARG00000076995Danio rerio
 Q91WA6ENSMUSG00000022552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBCK1 / Q9BYM8 / RANBP2-type and C3HC4-type zinc finger containing 1ENSG0000012582624


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR026168  SHARPIN
 IPR029071  Ubiquitin-like domain superfamily
 IPR031912  Sharpin, PH domain
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0030262 apoptotic nuclear changes IEA
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0050728 negative regulation of inflammatory response ISS
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0097039 protein linear polyubiquitination IDA
 biological_processGO:2000348 regulation of CD40 signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0071797 LUBAC complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000154124 OTULIN / Q96BN8 / OTU deubiquitinase with linear linkage specificity  / complex / reaction
 ENSG00000092098 RNF31 / Q96EP0 / ring finger protein 31  / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000161681 Q9Y566 / SHANK1 / SH3 and multiple ankyrin repeat domains 1  / reaction / complex
 ENSG00000125826 RBCK1 / Q9BYM8 / RANBP2-type and C3HC4-type zinc finger containing 1  / complex
 ENSG00000162105 Q9UPX8 / SHANK2 / SH3 and multiple ankyrin repeat domains 2  / reaction / complex






 

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