ENSDARG00000076995


Danio rerio

Features
Gene ID: ENSDARG00000076995
  
Biological name :sharpin
  
Synonyms : SHANK-associated RH domain interacting protein / sharpin
  
Possible biological names infered from orthology : Q91WA6 / Q9H0F6 / SHANK associated RH domain interactor
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 354424
Gene end: 364839
  
Corresponding Affymetrix probe sets: Dr.14025.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000128247
NCBI entrez gene - 793673     See in Manteia.
RefSeq - XM_001333445
swissprot - X1WDE8
ZFIN ID - ZDB-GENE-101223-1
Ensembl - ENSDARG00000076995
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9H0F6ENSG00000179526Homo sapiens
 Q91WA6ENSMUSG00000022552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A9JTG5 / shrprbck1r / sharpin and rbck1 related / Q9H0F6* / Q91WA6* / SHARPIN* / SHANK associated RH domain interactor*ENSDARG0000005987146
rbck1 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / Q9WUB0* / RANBP2-type and C3HC4-type zinc finger containing 1*ENSDARG0000003195417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR011993  PH-like domain superfamily
 IPR026168  SHARPIN
 IPR029071  Ubiquitin-like domain superfamily
 IPR031912  Sharpin, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0048592 eye morphogenesis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0071600 otic vesicle morphogenesis IMP
 biological_processGO:0097039 protein linear polyubiquitination IBA
 cellular_componentGO:0071797 LUBAC complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain malformed , abnormal
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 ZFA:0000051 otic vesicle otic vesicle malformed , abnormal
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 ZFA:0000217 inner ear inner ear decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSDARG00000031954 rbck1 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / Q9WUB0* / RANBP2-type and C3HC4-type zinc finger containing 1*  / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex / reaction






 

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