ENSMUSG00000027466


Mus musculus

Features
Gene ID: ENSMUSG00000027466
  
Biological name :Rbck1
  
Synonyms : Q9WUB0 / RanBP-type and C3HC4-type zinc finger containing 1 / Rbck1
  
Possible biological names infered from orthology : Q9BYM8 / RANBP2-type and C3HC4-type zinc finger containing 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 152316334
Gene end: 152332653
  
Corresponding Affymetrix probe sets: 10488594 (MoGene1.0st)   1415792_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028964
Ensembl peptide - ENSMUSP00000105473
Ensembl peptide - ENSMUSP00000118592
NCBI entrez gene - 24105     See in Manteia.
MGI - MGI:1344372
RefSeq - XM_017318025
RefSeq - NM_001083921
RefSeq - NM_019705
RefSeq - XM_006499445
RefSeq - XM_006499446
RefSeq - XM_006499447
RefSeq Peptide - NP_001077390
RefSeq Peptide - NP_062679
swissprot - F6VII1
swissprot - Q9WUB0
Ensembl - ENSMUSG00000027466
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbck1ENSDARG00000031954Danio rerio
 RBCK1ENSG00000125826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91WA6 / Sharpin / Q9H0F6* / SHANK associated RH domain interactor*ENSMUSG0000002255217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001841  Zinc finger, RING-type
 IPR001876  Zinc finger, RanBP2-type
 IPR002867  IBR domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR026261  RanBP-type and C3HC4-type zinc finger-containing protein 1
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR029071  Ubiquitin-like domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0050852 T cell receptor signaling pathway ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0060546 negative regulation of necroptotic process IGI
 biological_processGO:0097039 protein linear polyubiquitination ISO
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0071797 LUBAC complex ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1(MYC/ERT)Hsc/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction / complex
 ENSMUSG00000022552 Q91WA6 / Sharpin / Q9H0F6* / SHANK associated RH domain interactor*  / complex
 ENSMUSG00000047098 Rnf31 / Q924T7 / E3 ubiquitin-protein ligase RNF31 / Q96EP0* / AL136295.5* / ring finger protein 31*  / complex
 ENSMUSG00000046034 Otulin / Q3UCV8 / Ubiquitin thioesterase otulin / Q96BN8* / OTU deubiquitinase with linear linkage specificity*  / complex / reaction






 

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