ENSMUSG00000046034


Mus musculus

Features
Gene ID: ENSMUSG00000046034
  
Biological name :Otulin
  
Synonyms : Otulin / Q3UCV8 / Ubiquitin thioesterase otulin
  
Possible biological names infered from orthology : OTU deubiquitinase with linear linkage specificity / Q96BN8
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B1
Gene start: 27542635
Gene end: 27630693
  
Corresponding Affymetrix probe sets: 10427910 (MoGene1.0st)   1427966_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057893
Ensembl peptide - ENSMUSP00000154117
Ensembl peptide - ENSMUSP00000154705
NCBI entrez gene - 432940     See in Manteia.
MGI - MGI:3577015
RefSeq - XM_006520105
RefSeq - NM_001013792
RefSeq - XM_006520104
RefSeq Peptide - NP_001013814
swissprot - Q3UCV8
Ensembl - ENSMUSG00000046034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otulinaENSDARG00000073931Danio rerio
 otulinbENSDARG00000079886Danio rerio
 OTULINENSGALG00000019543Gallus gallus
 OTULINENSG00000154124Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TVP5 / Fam105a / Inactive ubiquitin thioesterase FAM105A / Q9NUU6* / family with sequence similarity 105 member A*ENSMUSG0000005606925


Protein motifs (from Interpro)
Interpro ID Name
 IPR023235  FAM105
 IPR023237  Ubiquitin thioesterase otulin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:1990108 protein linear deubiquitination IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0071797 LUBAC complex IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0001072 abnormal vestibulocochlear nerve morphology "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

Allelic Composition: Otulinm8Sapc/Otulinm8Sapc
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

Allelic Composition: Otulinm8Sapc/Otulinm8Sapc
Genetic Background: Not Specified

 MP:0012730 abnormal internal carotid artery morphology "any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [MGI:anna]
Show

Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

Allelic Composition: Otulinm8Sapc/Otulinm8Sapc
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027466 Rbck1 / Q9WUB0 / RanBP-type and C3HC4-type zinc finger containing 1 / Q9BYM8* / RANBP2-type and C3HC4-type zinc finger containing 1*  / reaction / complex
 ENSMUSG00000022552 Q91WA6 / Sharpin / Q9H0F6* / SHANK associated RH domain interactor*  / reaction / complex
 ENSMUSG00000047098 Rnf31 / Q924T7 / E3 ubiquitin-protein ligase RNF31 / Q96EP0* / AL136295.5* / ring finger protein 31*  / reaction / complex
 ENSMUSG00000008348 Ubc / P0CG50 / ubiquitin C / P0CG48*  / reaction






 

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