ENSMUSG00000020275


Mus musculus

Features
Gene ID: ENSMUSG00000020275
  
Biological name :Rel
  
Synonyms : Rel / reticuloendotheliosis oncogene
  
Possible biological names infered from orthology : Q04864 / REL proto-oncogene, NF-kB subunit
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A3.2
Gene start: 23736847
Gene end: 23770970
  
Corresponding Affymetrix probe sets: 10384725 (MoGene1.0st)   1420710_at (Mouse Genome 430 2.0 Array)   1436196_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099928
NCBI entrez gene - 19696     See in Manteia.
MGI - MGI:97897
RefSeq - NM_009044
RefSeq Peptide - NP_033070
swissprot - A4QPD3
Ensembl - ENSMUSG00000020275
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 relENSDARG00000055276Danio rerio
 RELENSGALG00000007845Gallus gallus
 RELENSG00000162924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*ENSMUSG0000002492737
Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*ENSMUSG0000002816330
Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*ENSMUSG0000002522530
Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*ENSMUSG0000000298330


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030505  Proto-oncogene c-Rel
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0032688 negative regulation of interferon-beta production IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olfr151tm25Mom/?,Olfr160tm6Mom/?,Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Itgamm1Btlr/Itgam+
Genetic Background: C57BL/6J-Itgamm1Btlr

Allelic Composition: RelM1Btlr/Rel+
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

Allelic Composition: RelM1Btlr/Rel+
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

Allelic Composition: RelM1Btlr/Rel+
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesdtm2.1Bch/Tyrc-3YPSd
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6 * C57BL/6J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf4atm1.1Gonz/Hnf4atm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8a6J/Scn8a6J
Genetic Background: C57BL/6J-Scn8a6J/J

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

Allelic Composition: RelM1Btlr/Rel+
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0002814 hyperchromasia "increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

Allelic Composition: RelM1Btlr/Rel+
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Reltm1Hcl/Rel+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

Allelic Composition: RelM1Btlr/Rel+
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008093 abnormal memory B cell number "anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008112 abnormal monocyte differentiation "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Reltm1Brv/Reltm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: RelM1Btlr/RelM1Btlr
Genetic Background: C57BL/6J-RelM1Btlr

Allelic Composition: RelM1Btlr/Rel+
Genetic Background: C57BL/6J-RelM1Btlr

 MP:0030582 abnormal hair follicle placode formation "any anomaly in the developmental process in which a hair placode forms; in mouse, hair placode formation is initiated at ~E13.5 in response to the first dermal signal originating from dermal fibroblasts; the resulting primary hair placode cells signal to the underlying dermis, triggering formation of dermal condensates that will coordinate further differentiation of hair-forming cells; hair placode formation progresses through 3 successive waves (1) primary hair placodes form at E14.5 and produce guard hair, (2) secondary hair placodes form at E16-17 and produce awl hair, and (3) the third wave of hair follicle induction produces tertiary placodes and generate zig-zag hair" [GO:0060789, https://discovery.lifemapsc.com/in-vivo-development/hair/hair-follicle/primary-hair-placode-cells]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / complex
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / complex
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / complex
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / reaction / complex






 

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