ENSMUSG00000029686


Mus musculus

Features
Gene ID: ENSMUSG00000029686
  
Biological name :Cul1
  
Synonyms : Cul1 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q9WTX6
  
Possible biological names infered from orthology : cullin 1 / Q13616
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.3
Gene start: 47453398
Gene end: 47526139
  
Corresponding Affymetrix probe sets: 10537882 (MoGene1.0st)   1448174_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144845
Ensembl peptide - ENSMUSP00000114959
Ensembl peptide - ENSMUSP00000121608
Ensembl peptide - ENSMUSP00000122702
Ensembl peptide - ENSMUSP00000031697
NCBI entrez gene - 26965     See in Manteia.
MGI - MGI:1349658
RefSeq - XM_006506190
RefSeq - NM_001355551
RefSeq - NM_012042
RefSeq - XM_006506188
RefSeq - XM_006506189
RefSeq Peptide - NP_001342479
RefSeq Peptide - NP_001342480
RefSeq Peptide - NP_036172
swissprot - Q3TPM3
swissprot - D3Z2H3
swissprot - D3YUS8
swissprot - Q9WTX6
swissprot - A0A0N4SUW1
Ensembl - ENSMUSG00000029686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul1aENSDARG00000019239Danio rerio
 cul1bENSDARG00000007691Danio rerio
 CUL1ENSGALG00000036941Gallus gallus
 CUL1ENSG00000055130Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cul2 / Q9D4H8 / Cullin-2 / Q13617*ENSMUSG0000002423136
Cul3 / Q9JLV5 / Cullin-3 / Q13618*ENSMUSG0000000436430
Cul4a / Q3TCH7 / Cullin-4A / Q13619*ENSMUSG0000003144630
Cul4b / A2A432 / Cullin-4B / Q13620*ENSMUSG0000003109530
Cul5 / cullin 5 / Q93034*ENSMUSG0000003203029


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IC
 biological_processGO:0006513 protein monoubiquitination IGI
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex ISO
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IC


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Cul1tmTye/Cul1tmTye
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Cul1tmTye/Cul1tmTye
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Cul1tmTye/Cul1tmTye
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cul1tmTye/Cul1tmTye
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Cul1tmTye/Cul1tmTye
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / complex
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / reaction / complex
 ENSMUSG00000020114 Cand1 / Q6ZQ38 / Cullin-associated NEDD8-dissociated protein 1 / Q86VP6* / cullin associated and neddylation dissociated 1*  / complex / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / reaction / complex
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSMUSG00000024235 Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000022070 Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*  / complex / reaction
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / reaction / complex
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / complex / reaction
 ENSMUSG00000066640 Fbxl18 / F-box and leucine rich repeat protein 18 / Q96ME1*  / complex
 ENSMUSG00000002068 Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*  / reaction / complex
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / complex / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / complex / reaction
 ENSMUSG00000019773 Fbxo5 / Q7TSG3 / F-box only protein 5 / Q9UKT4* / F-box protein 5*  / reaction / complex
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex
 ENSMUSG00000028212 Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*  / reaction / complex
 ENSMUSG00000051355 Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*  / reaction / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000048787 Q8K0V2 / Dcun1d3 / DCN1-like protein 3 / Q8IWE4* / defective in cullin neddylation 1 domain containing 3*  / reaction / complex
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex / reaction
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / complex / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / complex / reaction
 ENSMUSG00000005268 Prlr / Q08501 / prolactin receptor / P16471*  / complex / reaction
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000027496 Aurka / P97477 / Aurora kinase A / O14965*  / complex / reaction
 ENSMUSG00000059866 Tnip2 / Q99JG7 / TNFAIP3 interacting protein 2 / Q8NFZ5*  / reaction / complex
 ENSMUSG00000028086 Fbxw7 / Q8VBV4 / F-box/WD repeat-containing protein 7 / Q969H0* / F-box and WD repeat domain containing 7*  / complex
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / reaction / complex
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / reaction / complex
 ENSMUSG00000002983 Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*  / reaction / complex
 ENSMUSG00000043556 Fbxl7 / Q5BJ29 / F-box/LRR-repeat protein 7 / Q9UJT9* / F-box and leucine rich repeat protein 7*  / complex / reaction
 ENSMUSG00000039753 Fbxl5 / Q8C2S5 / F-box/LRR-repeat protein 5 / Q9UKA1* / F-box and leucine rich repeat protein 5*  / reaction / complex
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex
 ENSMUSG00000025225 Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*  / complex / reaction
 ENSMUSG00000020275 Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*  / reaction / complex






 

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