ENSMUSG00000066640


Mus musculus

Features
Gene ID: ENSMUSG00000066640
  
Biological name :Fbxl18
  
Synonyms : F-box and leucine rich repeat protein 18 / Fbxl18
  
Possible biological names infered from orthology : Q96ME1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 142866946
Gene end: 142895421
  
Corresponding Affymetrix probe sets: 10535372 (MoGene1.0st)   1456281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106394
Ensembl peptide - ENSMUSP00000041700
NCBI entrez gene - 231863     See in Manteia.
MGI - MGI:2444450
RefSeq - NM_001033312
RefSeq - XM_006504693
RefSeq - XM_006504694
RefSeq Peptide - NP_001028484
swissprot - F8VQK6
swissprot - E9PYR1
Ensembl - ENSMUSG00000066640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl18ENSDARG00000007443Danio rerio
 FBXL18ENSGALG00000004611Gallus gallus
 FBXL18ENSG00000155034Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex






 

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contact: otassy@igbmc.fr