ENSG00000155034


Homo sapiens

Features
Gene ID: ENSG00000155034
  
Biological name :FBXL18
  
Synonyms : F-box and leucine rich repeat protein 18 / FBXL18 / Q96ME1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p22.1
Gene start: 5431335
Gene end: 5513798
  
Corresponding Affymetrix probe sets: 1553359_at (Human Genome U133 Plus 2.0 Array)   1553361_x_at (Human Genome U133 Plus 2.0 Array)   215068_s_at (Human Genome U133 Plus 2.0 Array)   216395_at (Human Genome U133 Plus 2.0 Array)   220896_at (Human Genome U133 Plus 2.0 Array)   227500_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371805
Ensembl peptide - ENSP00000415064
Ensembl peptide - ENSP00000444797
Ensembl peptide - ENSP00000481397
Ensembl peptide - ENSP00000405896
NCBI entrez gene - 80028     See in Manteia.
OMIM - 609084
RefSeq - XM_011515532
RefSeq - NM_001321213
RefSeq - NM_024963
RefSeq - XM_011515531
RefSeq Peptide - NP_001308142
RefSeq Peptide - NP_079239
swissprot - Q96D16
swissprot - H0Y6I6
swissprot - Q96ME1
swissprot - A0A024R857
Ensembl - ENSG00000155034
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl18ENSDARG00000007443Danio rerio
 FBXL18ENSGALG00000004611Gallus gallus
 Fbxl18ENSMUSG00000066640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex






 

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contact: otassy@igbmc.fr