ENSG00000055130


Homo sapiens

Features
Gene ID: ENSG00000055130
  
Biological name :CUL1
  
Synonyms : CUL1 / cullin 1 / Q13616
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q36.1
Gene start: 148697914
Gene end: 148801036
  
Corresponding Affymetrix probe sets: 207614_s_at (Human Genome U133 Plus 2.0 Array)   238509_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473318
Ensembl peptide - ENSP00000482123
Ensembl peptide - ENSP00000326804
Ensembl peptide - ENSP00000387160
NCBI entrez gene - 8454     See in Manteia.
OMIM - 603134
RefSeq - XM_017012723
RefSeq - XM_011516629
RefSeq - XM_011516630
RefSeq - XM_011516631
RefSeq - XM_011516632
RefSeq - NM_003592
RefSeq - XM_005250060
RefSeq Peptide - NP_003583
swissprot - A0A0C4DGX4
swissprot - A0A090N7U0
swissprot - Q13616
Ensembl - ENSG00000055130
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul1aENSDARG00000019239Danio rerio
 cul1bENSDARG00000007691Danio rerio
 CUL1ENSGALG00000036941Gallus gallus
 Cul1ENSMUSG00000029686Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUL2 / Q13617 / cullin 2ENSG0000010809437
CUL3 / Q13618 / cullin 3ENSG0000003625730
CUL4A / Q13619 / cullin 4AENSG0000013984230
CUL4B / Q13620 / cullin 4BENSG0000015829030
CUL5 / Q93034 / cullin 5ENSG0000016626629


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010265 SCF complex assembly TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0097193 intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISS
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction / complex
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction / complex
 ENSG00000105173 CCNE1 / P24864 / cyclin E1  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / reaction / complex
 ENSG00000109670 FBXW7 / Q969H0 / F-box and WD repeat domain containing 7  / complex
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / reaction / complex
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex
 ENSG00000043093 Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1  / complex / reaction
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / complex / reaction
 ENSG00000175305 CCNE2 / O96020 / cyclin E2  / reaction / complex
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / complex
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / complex / reaction
 ENSG00000168884 TNIP2 / Q8NFZ5 / TNFAIP3 interacting protein 2  / reaction / complex
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000183580 FBXL7 / Q9UJT9 / F-box and leucine rich repeat protein 7  / complex / reaction
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / reaction / complex
 ENSG00000148400 NOTCH1 / P46531  / reaction / complex
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / reaction / complex
 ENSG00000173207 CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B  / complex / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / reaction / complex
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / reaction / complex
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / reaction / complex
 ENSG00000172179 PRL / P01236 / prolactin  / reaction / complex
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / complex / reaction
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / reaction / complex
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / complex / reaction
 ENSG00000155034 FBXL18 / Q96ME1 / F-box and leucine rich repeat protein 18  / complex
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / reaction / complex
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / complex / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / reaction / complex
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / reaction / complex
 ENSG00000111530 CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1  / reaction / complex
 ENSG00000188215 Q8IWE4 / DCUN1D3 / defective in cullin neddylation 1 domain containing 3  / reaction / complex
 ENSG00000118564 FBXL5 / Q9UKA1 / F-box and leucine rich repeat protein 5  / reaction / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr