ENSG00000118564


Homo sapiens

Features
Gene ID: ENSG00000118564
  
Biological name :FBXL5
  
Synonyms : F-box and leucine rich repeat protein 5 / FBXL5 / Q9UKA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p15.32
Gene start: 15604539
Gene end: 15681679
  
Corresponding Affymetrix probe sets: 209004_s_at (Human Genome U133 Plus 2.0 Array)   209005_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421070
Ensembl peptide - ENSP00000426993
Ensembl peptide - ENSP00000425541
Ensembl peptide - ENSP00000425472
Ensembl peptide - ENSP00000425027
Ensembl peptide - ENSP00000424423
Ensembl peptide - ENSP00000423961
Ensembl peptide - ENSP00000422049
Ensembl peptide - ENSP00000344866
Ensembl peptide - ENSP00000408679
NCBI entrez gene - 26234     See in Manteia.
OMIM - 605655
RefSeq - XM_017008019
RefSeq - NM_001193534
RefSeq - NM_001193535
RefSeq - NM_012161
RefSeq - XM_006713959
RefSeq - XM_011513831
RefSeq - XM_011513832
RefSeq - XM_011513833
RefSeq Peptide - NP_001180463
RefSeq Peptide - NP_001180464
RefSeq Peptide - NP_036293
swissprot - D6RCR7
swissprot - D6RBW7
swissprot - D6RB50
swissprot - D6R9Y4
swissprot - D6RED6
swissprot - H0Y9Y0
swissprot - H0YAG2
swissprot - Q9UKA1
swissprot - D6RHC3
Ensembl - ENSG00000118564
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl5ENSDARG00000043046Danio rerio
 FBXL5ENSGALG00000014510Gallus gallus
 Fbxl5ENSMUSG00000039753Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR012312  Haemerythrin-like
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0016567 protein ubiquitination NAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IEA
 cellular_componentGO:0000151 ubiquitin ligase complex NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Iron uptake and transport
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / reaction / complex






 

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