ENSMUSG00000039753


Mus musculus

Features
Gene ID: ENSMUSG00000039753
  
Biological name :Fbxl5
  
Synonyms : F-box/LRR-repeat protein 5 / Fbxl5 / Q8C2S5
  
Possible biological names infered from orthology : F-box and leucine rich repeat protein 5 / Q9UKA1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 43744615
Gene end: 43821638
  
Corresponding Affymetrix probe sets: 10529801 (MoGene1.0st)   1433441_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120338
Ensembl peptide - ENSMUSP00000143703
Ensembl peptide - ENSMUSP00000142582
Ensembl peptide - ENSMUSP00000045792
Ensembl peptide - ENSMUSP00000084733
Ensembl peptide - ENSMUSP00000109681
Ensembl peptide - ENSMUSP00000112444
Ensembl peptide - ENSMUSP00000113557
Ensembl peptide - ENSMUSP00000116720
NCBI entrez gene - 242960     See in Manteia.
MGI - MGI:2152883
RefSeq - NM_001159963
RefSeq - NM_178729
RefSeq Peptide - NP_001153435
RefSeq Peptide - NP_848844
swissprot - Q8C2S5
swissprot - A0A0G2JE06
swissprot - F6W6I1
swissprot - F7BZC4
swissprot - D3Z584
Ensembl - ENSMUSG00000039753
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl5ENSDARG00000043046Danio rerio
 FBXL5ENSGALG00000014510Gallus gallus
 FBXL5ENSG00000118564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR012312  Haemerythrin-like
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0055072 iron ion homeostasis ISO
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005506 iron ion binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Iron uptake and transport
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Adam17tm1Imx/Adam17woe
Genetic Background: involves: 129 * C57BL/6

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei
Genetic Background: involves: C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Adam17tm1Imx/Adam17woe
Genetic Background: involves: 129 * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei
Genetic Background: involves: C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0005032 abnormal ectoplacental cone 
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Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei
Genetic Background: involves: C57BL/6

 MP:0008743 decreased liver iron level "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Adam17tm1Imx/Adam17woe
Genetic Background: involves: 129 * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5Gt(OST386421)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011897 decreased circulating unsaturated transferrin level "reduction in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Fbxl5tm1Kei/Fbxl5tm1Kei,Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Fbxl5tm1Kei Ireb2tm1Roua

 MP:0012356 increased prothrombin time "increased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]
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Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0012359 increased partial thromboplastin time "increased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
Show

Allelic Composition: Fbxl5tm2.1Kei/Fbxl5tm2.1Kei,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0020369 increased intestinal iron level "increase in the amount of iron present in the large or small intestinal tissue" [MGI:Anna]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction






 

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