ENSG00000173207


Homo sapiens

Features
Gene ID: ENSG00000173207
  
Biological name :CKS1B
  
Synonyms : CDC28 protein kinase regulatory subunit 1B / CKS1B / P61024
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.3
Gene start: 154974653
Gene end: 154979249
  
Corresponding Affymetrix probe sets: 201897_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000311083
Ensembl peptide - ENSP00000357421
Ensembl peptide - ENSP00000357424
NCBI entrez gene - 1163     See in Manteia.
OMIM - 116900
RefSeq - NM_001826
RefSeq Peptide - NP_001817
swissprot - P61024
swissprot - Q5T178
swissprot - Q5T179
swissprot - Q9BZU3
Ensembl - ENSG00000173207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cks1bENSDARG00000007971Danio rerio
 CKS1BENSGALG00000028664Gallus gallus
 Cks1brtENSMUSG00000062687Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CKS2 / P33552 / CDC28 protein kinase regulatory subunit 2ENSG0000012397578


Protein motifs (from Interpro)
Interpro ID Name
 IPR000789  Cyclin-dependent kinase, regulatory subunit
 IPR036858  Cyclin-dependent kinase, regulatory subunit superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IBA
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0061575 cyclin-dependent protein serine/threonine kinase activator activity IBA


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction / complex
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction / complex
 ENSG00000105173 CCNE1 / P24864 / cyclin E1  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / reaction / complex
 ENSG00000175305 CCNE2 / O96020 / cyclin E2  / reaction / complex
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / reaction / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex






 

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