ENSG00000103479


Homo sapiens

Features
Gene ID: ENSG00000103479
  
Biological name :RBL2
  
Synonyms : Q08999 / RBL2 / RB transcriptional corepressor like 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q12.2
Gene start: 53433977
Gene end: 53491649
  
Corresponding Affymetrix probe sets: 212331_at (Human Genome U133 Plus 2.0 Array)   212332_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262133
Ensembl peptide - ENSP00000443744
Ensembl peptide - ENSP00000462464
NCBI entrez gene - 5934     See in Manteia.
OMIM - 180203
RefSeq - XM_017023513
RefSeq - NM_001323608
RefSeq - NM_001323609
RefSeq - NM_001323610
RefSeq - NM_001323611
RefSeq - NM_005611
RefSeq - XM_011523253
RefSeq Peptide - NP_001310537
RefSeq Peptide - NP_001310538
RefSeq Peptide - NP_001310539
RefSeq Peptide - NP_001310540
RefSeq Peptide - NP_005602
swissprot - J3KSF7
swissprot - F5H837
swissprot - Q08999
Ensembl - ENSG00000103479
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbl2ENSDARG00000045636Danio rerio
 RBL2ENSGALG00000003663Gallus gallus
 Rbl2ENSMUSG00000031666Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBL1 / P28749 / RB transcriptional corepressor like 1ENSG0000008083948
RB1 / P06400 / RB transcriptional corepressor 1ENSG0000013968722


Protein motifs (from Interpro)
Interpro ID Name
 IPR002719  Retinoblastoma-associated protein, B-box
 IPR002720  Retinoblastoma-associated protein, A-box
 IPR013763  Cyclin-like
 IPR015030  Retinoblastoma-associated protein, C-terminal
 IPR024599  Retinoblastoma-associated protein, N-terminal
 IPR028308  Retinoblastoma-like protein 2
 IPR028309  Retinoblastoma protein family
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0043550 regulation of lipid kinase activity IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Activation of E2F1 target genes at G1/S
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex
 ENSG00000133740 E2F5 / Q15329 / E2F transcription factor 5  / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex
 ENSG00000173207 CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B  / complex / reaction
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / reaction / complex
 ENSG00000205250 E2F4 / Q16254 / E2F transcription factor 4  / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction






 

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