ENSG00000114126


Homo sapiens

Features
Gene ID: ENSG00000114126
  
Biological name :TFDP2
  
Synonyms : Q14188 / TFDP2 / transcription factor Dp-2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q23
Gene start: 141944428
Gene end: 142149544
  
Corresponding Affymetrix probe sets: 203588_s_at (Human Genome U133 Plus 2.0 Array)   203589_s_at (Human Genome U133 Plus 2.0 Array)   226157_at (Human Genome U133 Plus 2.0 Array)   244043_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419507
Ensembl peptide - ENSP00000419036
Ensembl peptide - ENSP00000419540
Ensembl peptide - ENSP00000473436
Ensembl peptide - ENSP00000439782
Ensembl peptide - ENSP00000420657
Ensembl peptide - ENSP00000420616
Ensembl peptide - ENSP00000420599
Ensembl peptide - ENSP00000420456
Ensembl peptide - ENSP00000417108
Ensembl peptide - ENSP00000417220
Ensembl peptide - ENSP00000417384
Ensembl peptide - ENSP00000417585
Ensembl peptide - ENSP00000417726
Ensembl peptide - ENSP00000418122
Ensembl peptide - ENSP00000418590
Ensembl peptide - ENSP00000418971
NCBI entrez gene - 7029     See in Manteia.
OMIM - 602160
RefSeq - XM_017007105
RefSeq - XM_011513107
RefSeq - XM_011513108
RefSeq - XM_011513109
RefSeq - XM_011513111
RefSeq - XM_017007091
RefSeq - XM_017007092
RefSeq - XM_017007093
RefSeq - XM_017007094
RefSeq - XM_017007095
RefSeq - XM_017007096
RefSeq - XM_017007097
RefSeq - XM_017007098
RefSeq - XM_017007099
RefSeq - XM_017007100
RefSeq - XM_017007101
RefSeq - XM_017007102
RefSeq - XM_017007104
RefSeq - NM_001178138
RefSeq - NM_001178139
RefSeq - NM_001178140
RefSeq - NM_001178141
RefSeq - NM_001178142
RefSeq - NM_006286
RefSeq - XM_005247731
RefSeq - XM_011513101
RefSeq - XM_011513102
RefSeq - XM_011513106
RefSeq Peptide - NP_001171611
RefSeq Peptide - NP_001171612
RefSeq Peptide - NP_001171613
RefSeq Peptide - NP_006277
RefSeq Peptide - NP_001171609
RefSeq Peptide - NP_001171610
swissprot - F8WAY9
swissprot - H7C5C2
swissprot - R4GN09
swissprot - C9J461
swissprot - C9JTZ9
swissprot - Q14188
swissprot - C9JNB6
swissprot - C9JCY5
swissprot - C9J977
swissprot - C9J872
swissprot - C9J5D5
Ensembl - ENSG00000114126
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfdp2ENSDARG00000042835Danio rerio
 TFDP2ENSGALG00000025759Gallus gallus
 Tfdp2ENSMUSG00000032411Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TFDP1 / Q14186 / transcription factor Dp-1ENSG0000019817658
TFDP3 / Q5H9I0 / transcription factor Dp family member 3ENSG0000018343446


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR014889  Transcription factor DP, C-terminal
 IPR015648  Transcription factor DP
 IPR028314  Transcription factor DP2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003712 transcription coregulator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI


Pathways (from Reactome)
Pathway description
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
G0 and Early G1
Pre-NOTCH Transcription and Translation
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Activation of E2F1 target genes at G1/S
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / complex / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000101412 E2F1 / Q01094 / E2F transcription factor 1  / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / reaction / complex
 ENSG00000080839 RBL1 / P28749 / RB transcriptional corepressor like 1  / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / reaction / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000112242 E2F3 / O00716 / E2F transcription factor 3  / complex
 ENSG00000007968 E2F2 / Q14209 / E2F transcription factor 2  / complex
 ENSG00000133740 E2F5 / Q15329 / E2F transcription factor 5  / complex
 ENSG00000205250 E2F4 / Q16254 / E2F transcription factor 4  / complex






 

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