ENSG00000205250


Homo sapiens

Features
Gene ID: ENSG00000205250
  
Biological name :E2F4
  
Synonyms : E2F4 / E2F transcription factor 4 / Q16254
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 67192169
Gene end: 67198918
  
Corresponding Affymetrix probe sets: 202248_at (Human Genome U133 Plus 2.0 Array)   38707_r_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454477
Ensembl peptide - ENSP00000457239
Ensembl peptide - ENSP00000458082
Ensembl peptide - ENSP00000458706
Ensembl peptide - ENSP00000368686
NCBI entrez gene - 1874     See in Manteia.
OMIM - 600659
RefSeq - NM_001950
RefSeq Peptide - NP_001941
swissprot - Q16254
swissprot - H3BMP3
swissprot - H3BTM3
swissprot - H3BVE4
swissprot - I3L1B6
Ensembl - ENSG00000205250
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f4ENSDARG00000101578Danio rerio
 E2F4ENSGALG00000001722Gallus gallus
 E2f4ENSMUSG00000014859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F5 / Q15329 / E2F transcription factor 5ENSG0000013374050
E2F2 / Q14209 / E2F transcription factor 2ENSG0000000796831
E2F3 / O00716 / E2F transcription factor 3ENSG0000011224228
E2F1 / Q01094 / E2F transcription factor 1ENSG0000010141227
E2F6 / O75461 / E2F transcription factor 6ENSG0000016901619


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR028312  Transcription factor E2F4
 IPR032198  E2F transcription factor, CC-MB domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037241  E2F-DP heterodimerization region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0002064 epithelial cell development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006884 cell volume homeostasis IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008015 blood circulation IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0044458 motile cilium assembly ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0098534 centriole assembly ISS
 biological_processGO:1903251 multi-ciliated epithelial cell differentiation ISS
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of E2F1 target genes at G1/S
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000080839 RBL1 / P28749 / RB transcriptional corepressor like 1  / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / reaction / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex






 

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