ENSDARG00000101578


Danio rerio

Features
Gene ID: ENSDARG00000101578
  
Biological name :e2f4
  
Synonyms : e2f4 / E2F transcription factor 4
  
Possible biological names infered from orthology : Q16254 / Q8R0K9 / Transcription factor E2F4
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 17405201
Gene end: 17419097
  
Corresponding Affymetrix probe sets: Dr.22502.1.A1_at (Zebrafish Array)   Dr.4922.1.A1_at (Zebrafish Array)   NM_213432_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000153444
Ensembl peptide - ENSDARP00000132304
NCBI entrez gene - 406741     See in Manteia.
RefSeq - NM_213432
RefSeq Peptide - NP_998597
swissprot - A0A0R4ICD5
ZFIN ID - ZDB-GENE-040426-2773
Ensembl - ENSDARG00000101578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E2F4ENSGALG00000001722Gallus gallus
 E2F4ENSG00000205250Homo sapiens
 E2f4ENSMUSG00000014859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
e2f5 / E2F transcription factor 5 / Q15329* / Q61502* / Transcription factor E2F5 *ENSDARG0000003881243
E2F2 / si:ch211-160f23.5 / P56931* / Q14209* / E2F transcription factor 2* / Transcription factor E2F2 *ENSDARG0000007923328
e2f1 / E2F transcription factor 1 / Q01094*ENSDARG0000010386826
e2f3 / E2F transcription factor 3 / O00716* / O35261* / Transcription factor E2F3 *ENSDARG0000007046326
si:ch211-195d17.2 / E2F6* / O54917* / O75461* / E2F transcription factor 6* / Transcription factor E2F6 *ENSDARG0000000811913


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015633  E2F Family
 IPR028312  Transcription factor E2F4
 IPR032198  E2F transcription factor, CC-MB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / reaction
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction / complex
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / reaction
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / reaction
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / complex
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / reaction / complex
 ENSDARG00000101637 ccnd1 / Q90459 / cyclin D1 / P24385* / P25322* / G1/S-specific cyclin-D1 *  / reaction






 

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