ENSDARG00000026577


Danio rerio

Features
Gene ID: ENSDARG00000026577
  
Biological name :cdk2
  
Synonyms : cdk2 / cyclin-dependent kinase 2
  
Possible biological names infered from orthology : P24941 / P97377
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 3301277
Gene end: 3308569
  
Corresponding Affymetrix probe sets: Dr.17883.1.S1_at (Zebrafish Array)   NM_213406_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000032448
NCBI entrez gene - 406715     See in Manteia.
RefSeq - NM_213406
RefSeq Peptide - NP_998571
swissprot - Q7ZWB1
ZFIN ID - ZDB-GENE-040426-2741
Ensembl - ENSDARG00000026577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDK2ENSGALG00000032699Gallus gallus
 CDK2ENSG00000123374Homo sapiens
 Cdk2ENSMUSG00000025358Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*ENSDARG0000008755465
cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *ENSDARG0000005668358
cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*ENSDARG0000007022847
cdk11b / cyclin-dependent kinase 11B / CDK11A* / Q9UQ88* / cyclin dependent kinase 11A*ENSDARG0000010254647
cdk4 / cyclin-dependent kinase 4 / P11802*ENSDARG0000008793746
cdk10 / cyclin-dependent kinase 10 / Q15131* / Q3UMM4*ENSDARG0000003425645
cdk21 / cyclin-dependent kinase 21ENSDARG0000003016340


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010033 response to organic substance IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030332 cyclin binding IBA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007657 ccnh / cyclin H / P51946* / Q61458*  / reaction
 ENSDARG00000002077 mnat1 / MNAT CDK-activating kinase assembly factor 1 / P51949* / P51948* / CDK-activating kinase assembly factor MAT1 * / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSDARG00000015254 fzr1a / fizzy/cell division cycle 20 related 1a / FZR1* / Q9R1K5* / Q9UM11* / Fizzy-related protein homolog * / fizzy and cell division cycle 20 related 1*  / complex / reaction
 ENSDARG00000010792 cdc25b / cell division cycle 25B / CDC25A* / P30305* / P30306* / P48964* / P30304* / cell division cycle 25A* / M-phase inducer phosphatase 1 * / M-phase inducer phosphatase 2 *  / reaction
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000051854 cdt1 / chromatin licensing and DNA replication factor 1 / Q8R4E9* / Q9H211* / DNA replication factor Cdt1 *  / reaction
 ENSDARG00000023584 cdc7 / cell division cycle 7 homolog (S. cerevisiae) / Q9Z0H0* / O00311* / cell division cycle 7* / Cell division cycle 7-related protein kinase *  / complex / reaction
 ENSDARG00000045815 mcm10 / Q5RHY1 / minichromosome maintenance 10 replication initiation factor / Q0VBD2* / Q7L590*  / complex / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSDARG00000007971 cks1b / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000074796 dbf4 / DBF4 zinc finger / A * / Q9QZ41* / Q9UBU7*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction / complex
 ENSDARG00000070463 e2f3 / E2F transcription factor 3 / O00716* / O35261* / Transcription factor E2F3 *  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000051916 cdk7 / cyclin-dependent kinase 7 / P50613* / Q03147*  / reaction
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / reaction / complex
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000043720 cdc45 / CDC45 cell division cycle 45 homolog (S. cerevisiae) / O75419* / Q9Z1X9* / cell division cycle 45* / Cell division control *  / reaction / complex
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / reaction / complex
 ENSDARG00000038812 e2f5 / E2F transcription factor 5 / Q15329* / Q61502* / Transcription factor E2F5 *  / reaction / complex
 ENSDARG00000093864 wee1 / WEE1 G2 checkpoint kinase / P30291* / P47810* / WEE 1 homolog 1 (S. pombe)*  / reaction
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / complex / reaction
 ENSDARG00000101578 e2f4 / E2F transcription factor 4 / Q16254*  / complex / reaction






 

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