ENSDARG00000043720


Danio rerio

Features
Gene ID: ENSDARG00000043720
  
Biological name :cdc45
  
Synonyms : cdc45 / CDC45 cell division cycle 45 homolog (S. cerevisiae)
  
Possible biological names infered from orthology : Cell division control / cell division cycle 45 / O75419 / Q9Z1X9
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 4734005
Gene end: 4760723
  
Corresponding Affymetrix probe sets: Dr.7974.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000064200
NCBI entrez gene - 406695     See in Manteia.
RefSeq - NM_213386
RefSeq Peptide - NP_998551
swissprot - Q7ZU79
ZFIN ID - ZDB-GENE-040426-2710
Ensembl - ENSDARG00000043720
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDC45ENSGALG00000001616Gallus gallus
 CDC45ENSG00000093009Homo sapiens
 Cdc45ENSMUSG00000000028Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003874  CDC45 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000727 double-strand break repair via break-induced replication IBA
 biological_processGO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0031938 regulation of chromatin silencing at telomere IBA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IBA
 biological_processGO:1902977 mitotic DNA replication preinitiation complex assembly IBA
 cellular_componentGO:0005656 nuclear pre-replicative complex IBA
 cellular_componentGO:0031261 DNA replication preinitiation complex IBA
 cellular_componentGO:0031298 replication fork protection complex IBA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003688 DNA replication origin binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0043138 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000023584 cdc7 / cell division cycle 7 homolog (S. cerevisiae) / Q9Z0H0* / O00311* / cell division cycle 7* / Cell division cycle 7-related protein kinase *  / complex / reaction
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / reaction / complex
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction / complex
 ENSDARG00000045815 mcm10 / Q5RHY1 / minichromosome maintenance 10 replication initiation factor / Q0VBD2* / Q7L590*  / reaction / complex
 ENSDARG00000074796 dbf4 / DBF4 zinc finger / A * / Q9QZ41* / Q9UBU7*  / complex / reaction






 

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